| Name | Glucoraphanin |
| Description | Glucoraphanin, the precursor of the widely extolled chemopreventive agent sulforaphane found in broccoli, has antioxidant activity. |
| Animal Research | Male C57BL/6JSlc mice are 7 weeks of age. The Nrf2 knockout (Nrf2?/?) mouse strain is used in the assay. After 1 week of acclimation, mice are fed normal chow (NC) (containing 2.2% dextrinized cornstarch, 10% kcal from fat), NC containing 0.3% glucoraphanin (NC-GR) (containing 2.2% extract powder), an HFD (containing 2.2% dextrinized cornstarch, 60% kcal from fat), or an HFD containing 0.3% glucoraphanin (HFD-GR) (containing 2.2% extract powder) for 14 weeks. Both the NC and the HFD containing cornstarch or glucoraphanin are prepared. All mice studied are maintained on a 12-h light/dark cycle at 24-26°C with free access to water and food [1]. |
| In vivo | Glucoraphanin reduces weight gain, enhances energy expenditure, improves insulin sensitivity, and glucose tolerance in HFD-fed mice, but it does not exert these effects in Nrf2-/-. It blocks HFD-induced reduction of Ucp1 protein levels in white adipose depots of wild-type mice but not in Nrf2-/-, alleviates HFD-induced hepatic steatosis and oxidative stress, and suppresses HFD-induced proinflammatory activation of macrophages in the liver and adipose tissue [1]. Additionally, pellets containing 0.1% Glucoraphanin (GF) significantly attenuate decreased social avoidance time and sucrose preference in stressed mice [2]. |
| Storage | store at low temperature,store under nitrogen,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 74 mg/mL (169.14 mM), Sonication is recommended.
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| Keywords | ReactiveOxygenSpecies | Reactive Oxygen Species | Inhibitor | inhibit | Glucoraphanin | Antioxidant |
| Inhibitors Related | Sucrose | Ethoxyquin | Aceglutamide | L-Pyroglutamic acid | Emtricitabine | Levulinic acid | D(+)-Raffinose pentahydrate | D-(+)-Trehalose dihydrate | Ethyl linoleate | Glycerol | Thymidine | Gluconate Calcium |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Bioactive Compound Library | Selected Plant-Sourced Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Ancient Chinese Classical Formulas Compound Library | Anti-Cancer Active Compound Library | Food as Medicine Compound Library |
United States
