Name | Glaucocalyxin A |
Description | 1. Glaucocalyxin A (Leukamenin F)-SBE-β-CD could be useful with a better solubility and sustained function in drug delivery. 2. Glaucocalyxin A activates caspase-3, decreases BAD phosphorylation, and reduces the expression of X-linked inhibitor of apoptosis protein. 3. Glaucocalyxin A inhibits Akt phosphorylation, suppresses proliferation, and promotes apoptosis in a dose-dependent manner, but not in normal glial cells. 4. Glaucocalyxin A inhibits collagen-stimulated tyrosine phosphorylation of Syk, LAT, and phospholipase Cγ2, the signaling events in collagen receptor GPⅥ pathway. 5. Glaucocalyxin A could potentially be developed as an antiplatelet and antithrombotic agent, can inhibit platelet p-selectin secretion and integrin activation by convulxin, is a GPVI selective ligand. |
Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc. : Soluble DMSO : 6.88 mg/mL (20.68 mM), Sonication is recommended.
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Keywords | Phosphoinositide 3-kinase | inhibit | Apoptosis | Protein kinase B | Glaucocalyxin A | PI3K | Akt | Inhibitor | PKB |
Inhibitors Related | Stavudine | TBHQ | 5-Fluorouracil | Meclizine dihydrochloride | Dextran sulfate sodium salt (MW 4500-5500) | Sodium 4-phenylbutyrate | Sorafenib | Tributyrin | Lidocaine hydrochloride | 2,3-Butanediol | Alginic acid | Oleic acid |
Related Compound Libraries | Anti-Tumor Natural Product Library | Terpene Natural Product Library | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Kinase Inhibitor Library | Natural Product Library | Inhibitor Library | Natural Product Library for HTS | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library |