| Name | Ginkgolide B |
| Description | Ginkgolide B (BN-52021) is a PAFR antagonist(IC50=3.6 μM) isolated from Ginkgo biloba. |
| In vitro | Oral administration of Ginkgolide B (50 mg/kg) before ischemia notably reduces neuronal damage in the hippocampus of rats. In a mouse model of focal transient ischemia, a 30-minute pretreatment with Ginkgolide B (100 mg/kg, s.c.) diminishes the area of infarction. Additionally, in animals anesthetized with pentobarbital or ethyl carbamate, Ginkgolide B, administered either intravenously (1 mg/kg) or orally (10 mg/kg), inhibits bronchoconstriction and increases hematocrit. |
| In vivo | Ginkgolide B effectively inhibits platelet-activating factor (PAF) receptors. In cystic cells, it modifies the Ras/MAPK signaling pathway, inducing cell differentiation. In EPC cells, Ginkgolide B promotes cell proliferation and endothelial gene expression by inducing the phosphorylation of eNOS, Akt, and p38, significantly enhancing vascular endothelial growth factor (VEGF)-induced migration responses. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 60 mg/mL (141.38 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (4.71 mM), Sonication is recommended.
Ethanol : 10.6 mg/mL (24.98 mM), Sonication is recommended.
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| Keywords | PAFR | Inhibitor | inhibit | Ginkgolide B | EndogenousMetabolite | Endogenous Metabolite | BN52021 | BN 52021 | Apoptosis |
| Inhibitors Related | Sucrose | Stavudine | Cysteamine hydrochloride | Daidzein | Guanidine hydrochloride | Tributyrin | Ferulic Acid | Glycerol | Thymidine | Naringin | Alginic acid | 3-Indoleacetic acid |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Terpene Natural Product Library | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library | Inhibitor Library | Immunology/Inflammation Compound Library | Bitter Compound library | Anti-infective Natural Product Library | Food as Medicine Compound Library | Anti-Cancer Active Compound Library |
United States
