| 名称 | Gentamicin sulfate |
| 描述 | Gentamicin sulfate (SCH9724) is a wide-spectrum, aminoglycoside antibiotic used to inhibit protein synthesis in sensitive organisms. |
| 体外活性 | METHODS: Fibroblasts, MDCK and LLC-PK1 cells were treated with Gentamicin sulfate (0-3 mM) for 4 days and apoptosis was detected by TUNEL assay.
RESULTS: The incidence of apoptosis was increased in all 3 cell lines, correlating almost directly with the extracellular concentration of Gentamicin sulfate and the incubation time, reaching 20-30% of all cells. [1] |
| 体内活性 | Gentamicin is the first choice aminoglycoside for the treatment of serious infections at present, with alternatives being amikacin, netilmicin, and tobramycin. Gentamicin preparations are commercially available in three forms, namely otic, ophthalmic, and topical based on the respective function to treat infections of ear canal, eye, and skin. Oral and injectable forms of gentamicin are found to exhibit effective antibacterial activity against Yersinia pestis as demonstrated in a mouse infection model[4]. Treatment with up to nine doses of methicillin or gentamicin shows an obvious reduction of bacteria on the foreign body[5]. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : Insoluble
H2O : 10 mM
|
| 关键字 | Gentamicin sulfate | Bacterial | Gentamicin | Gentamycin Sulfate | Inhibitor | inhibit | Meniere’s disease | Antibiotic | orally active | NSC82261 | Gentamicin Sulfate | SCH 9724 | glandular tularemia | NSC 82261 | SCH-9724 |
| 相关产品 | Dehydroacetic acid sodium | Chlorobutanol hemihydrate | Chitosan (MW 150000) | Ampicillin sodium | Doxycycline (hyclate) | Cefaclor monohydrate | Sulfamethoxazole sodium | Doxycycline | DDAC | Dimethyl sulfoxide | Meldrum's acid | Crystal Violet |
| 相关库 | 抗癌临床化合物库 | 天然产物库 | 微生物天然产物库 | 高通量筛选天然产物库 | 抗癌上市药物库 | 抗感染天然产物库 | 抗癌药物库 |
United States
