| Name | Gemigliptin Tartrate(911637-19-9 free base) |
| Description | Gemigliptin Tartrate (LC15-0444 tartrate) is a highly selective, reversible and competitive inhibitor of dipeptidyl peptidase-4 (DPP-4). It has an IC50 of 10.3 nM for human recombinant DPP-4. Gemigliptin tartrate exhibits potent anti-glycation properties. |
| In vitro | Gemigliptin tartrate inhibits the formation of AGE-BSA with IC50 of 11.69 mM[1]. Gemigliptin tartrate suppresses the cross-linking of preformed AGE-BSA with rat tail tendon collagen with an IC50 of 1.39 mM[1]. Gemigliptin tartrate is a competitive DPP-4 inhibitor with a Ki of 7.25 nM[2]. |
| In vivo | Gemigliptin tartrate inhibits AGEs formation and AGE cross-links in vivo[1]. Gemigliptin tartrate dose-dependently inhibits plasma DPP-4 activity in rats, dogs, and monkeys[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 90 mg/mL (140.75 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (5.16 mM), Sonication is recommended.
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| Keywords | type | products | peptidase-4 | mellitus | LC15-0444 Tartrate | LC15-0444 | Inhibitor | inhibit | glycation | Gemigliptin Tartrate(911637-19-9 free base) | Gemigliptin Tartrate(911637199 free base) | Gemigliptin Tartrate(911637 19 9 free base) | Gemigliptin | end | DPP-4 | DPP4 | DPP | Dipeptidyl Peptidase | dipeptidyl | diabetes | AGE | advanced |
| Inhibitors Related | (R)-MG-132 | Sitagliptin | Teneligliptin hydrobromide | Sitagliptin phosphate monohydrate | Anagliptin | TCH-165 | Linagliptin | Aprotinin | Vildagliptin | Alloxan monohydrate | 4'-Hydroxychalcone | Bortezomib |
| Related Compound Libraries | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compound Library | Approved Drug Library | Ubiquitination Compound Library | Protease Inhibitor Library | Drug Repurposing Compound Library | Inhibitor Library | Metabolism Compound Library | Clinical Compound Library | Bioactive Compounds Library Max |
United States
