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ChemicalBook Product Catalog Gemcitabine elaidate

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Gemcitabine elaidate NEW

$299.00 2mg

$449.00 5mg

Min. Order
Purity
Cas No210829-30-4
Supply Ability10g
Update time2025-10-27

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

VIP2Y

United States

United States

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Chemical Properties

Product Name	Gemcitabine elaidate
CAS No	210829-30-4
EC-No
Min. Order
Purity
Supply Ability	10g
Release date	2025/10/27

Product Introduction

Bioactivity

Name	Gemcitabine elaidate
Description	Gemcitabine elaidate (CP-4126), is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential antineoplastic activity. Upon hydrolysis intracellularly by esterases, the prodrug gemcitabine is converted into the active metabolites difluorodeoxycytidine di- and tri-phosphate (dFdCDP and dFdCTP) by deoxycytidine kinase. dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis.
In vitro	Gemcitabine analog Upon hydrolysis intracellularly by esterases, the prodrug gemcitabine is converted into the active metabolites difluorodeoxycytidine di- and tri-phosphate (dFdCDP and dFdCTP) by deoxycytidine kinase. dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis. Gemcitabine 5'-elaidic acid ester shows an enhanced cellular uptake and accumulation, resulting in increased conversion to active metabolites, compared to gemcitabine. This formulation of gemcitabine may be less susceptible to deamination and deactivation by deoxycytidine deaminase. Check for active clinical trials or closed clinical trials using this agent.
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO : 26 mg/mL (49.28 mM), Sonication is recommended.
Keywords	NucleosideAntimetabolite \| Nucleoside Antimetabolite/Analog \| Nucleoside Antimetabolite \| Inhibitor \| inhibit \| Gemcitabine elaidate \| Gemcitabine \| elaidate \| CP4126 \| CP 4126 \| CO101 \| CO 101 \| Autophagy \| Apoptosis \| anti-tumor \| Analog
Inhibitors Related	Stavudine \| Cysteamine hydrochloride \| Sodium 4-phenylbutyrate \| Hydroxychloroquine \| Guanidine hydrochloride \| Tributyrin \| Paeonol \| Naringin \| L-Ascorbic acid sodium salt \| Alginic acid \| Gefitinib \| Dextran sulfate sodium salt (MW 5000)

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