Name | Garcinol |
Description | Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity. Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 0.66 μM and 7.39 μM, respectively. |
In vitro | Garcinol (10-50 μM; 24-72 hours) induces apoptosis and inhibits the proliferation of HNSCC cells in a time- and dose-dependent manner, specifically in the cell lines CAL27 and UMSCC1. Additionally, Garcinol (50 μM; 1-6 hours) suppresses the phosphorylation and degradation of constitutive IκBα in a time-dependent manner. |
In vivo | Garcinolinduces significant inhibition of tumor growth. |
Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | Ethanol : 20 mg/mL (33.18 mM), Sonication and heating are recommended. DMSO : 20 mg/mL (33.18 mM), Sonication and heating are recommended.
|
Keywords | Inhibitor | HATs | PCAF | anti-cancer | Endogenous Metabolite | indica | anti-inflammatory | inhibit | HAT | Cholinesterase (ChE) | BChE | Garcinia | Apoptosis | Garcinol | Histone Acetyltransferase | anti-cholinesterase |
Inhibitors Related | Sucrose | Stavudine | Daidzein | Guanidine hydrochloride | Fumaric acid | Tributyrin | Ferulic Acid | Glycerol | Thymidine | Naringin |
Related Compound Libraries | Anti-Tumor Natural Product Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Rare Natural Product Library | Membrane Protein-targeted Compound Library | Selected Plant-Sourced Compound Library | Natural Product Library for HTS | Anti-Aging Compound Library | Bioactive Compounds Library Max |