Product Information Introduction:

Common Name	Gabapentin
CAS Number	60142-96-3	Molecular Weight	171.237
Density	1.1±0.1 g/cm3	Boiling Point	314.4±15.0 °C at 760 mmHg
Molecular Formula	C9H17NO2	Melting Point	162°C
MSDS	ChineseUSA	Flash Point	144.0±20.4 °C
Symbol	GHS07, GHS08	Signal Word	Danger

Chemical & Physical Properties:

Use of Gabapentin

Gabapentin (Neurontin) is a pharmaceutical drug, specifically a GABA analog. It was originally developed to treat epilepsy, and currently is also used to relieve neuropathic pain.IC50 Value: 140 nM (α2δ subunit of calcium channel) [1]Target: Calcium Channelin vitro: Gabapentin, baclofen and CGP 44532 all reduced the electrically stimulated release of [3H]glutamic acid (IC50=20 microM, 0.8 microM and 2 microM, respectively). Gabapentin was without effect on the release of [3H]GABA, whilst baclofen (IC50=8 microM) and CGP 44532 (IC50=1 microM) inhibited [3H]GABA release [2]. A large inhibition of calcium currents by gabapentin was observed in pyramidal neocortical cells (up to 34%). Significantly, the gabapentin-mediated inhibition of calcium currents saturated at particularly low concentrations (around 10 microM), at least in neocortical neurons (IC50 about 4 microM) [3].in vivo: Gabapentin produced an anti-allodynic effect over the 7-day period, reducing the expression of pro-inflammatory cytokines but increasing the expression of IL-10 (TNF-α, 316.0 ± 69.7 pg/mL vs 88.8 ± 24.4 pg/mL; IL-1β, 1,212.9 ± 104.5 vs 577.4 ± 97.1 pg/mL; IL-6, 254.0 ± 64.8 pg/mL vs 125.5 ± 44.1 pg/mL; IL-10, 532.1 ± 78.7 pg/mL vs 918.9 ± 63.1 pg/mL). The suppressive effect of gabapentin on pro-inflammatory cytokine expression was partially blocked by the anti-IL-10 antibody [4].Toxicity: No new safety signals or adverse event trends relating to GEn exposure were identified [5].Clinical trial: N/A

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2. Door to door shipping service is available. 3. Selecting raw materials strictly,our products are the highest purity. 4. Reasonable and competitive price. Provide the best and professional service. 5. Fast delivery of the samples ,samples from stock. Reliable shipping way. 6. Best after-service after shipment .

Company Profile:

Anhui Yisheng Technology Co., Ltd. was established in 2022, located in Hefei, Anhui Province, China. The company is a high-tech enterprise integrating inorganic chemical, organic chemical, pharmaceutical raw materials, pharmaceutical intermediates and other fine chemical products, product research and development, production, agency, sales in one.

We have a pharmaceutical raw material production factory and a reagent research and development center.We now have the most complete product line available.In addition, we also develop and produce tens of thousands of reagents.We also customize the business of synthetic various organic compounds as a supplement.We can synthesize almost all of the chemicals.Our goal is to survive by quality, by integrity for development, the company's products have been sold well in Europe sovereignty, Southeast Asia, the Middle East and other areas. Our company adheres to the concept of 'always providing customers with the best quality service', based on the modern information processing and good relationship network platform.Make us better serve our customers.

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