Gabapentin cas 60142-96-3
| Common Name | Gabapentin |
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| CAS Number | 60142-96-3 | Molecular Weight | 171.237 |
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| Density | 1.1±0.1 g/cm3 | Boiling Point | 314.4±15.0 °C at 760 mmHg |
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| Molecular Formula | C9H17NO2 | Melting Point | 162°C |
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| MSDS | ChineseUSA | Flash Point | 144.0±20.4 °C |
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Use of Gabapentin
Gabapentin (Neurontin) is a pharmaceutical drug, specifically a GABA analog. It was originally developed to treat epilepsy, and currently is also used to relieve neuropathic pain.IC50 Value: 140 nM (α2δ subunit of calcium channel) [1]Target: Calcium Channelin vitro: Gabapentin, baclofen and CGP 44532 all reduced the electrically stimulated release of [3H]glutamic acid (IC50=20 microM, 0.8 microM and 2 microM, respectively). Gabapentin was without effect on the release of [3H]GABA, whilst baclofen (IC50=8 microM) and CGP 44532 (IC50=1 microM) inhibited [3H]GABA release [2]. A large inhibition of calcium currents by gabapentin was observed in pyramidal neocortical cells (up to 34%). Significantly, the gabapentin-mediated inhibition of calcium currents saturated at particularly low concentrations (around 10 microM), at least in neocortical neurons (IC50 about 4 microM) [3].in vivo: Gabapentin produced an anti-allodynic effect over the 7-day period, reducing the expression of pro-inflammatory cytokines but increasing the expression of IL-10 (TNF-α, 316.0 ± 69.7 pg/mL vs 88.8 ± 24.4 pg/mL; IL-1β, 1,212.9 ± 104.5 vs 577.4 ± 97.1 pg/mL; IL-6, 254.0 ± 64.8 pg/mL vs 125.5 ± 44.1 pg/mL; IL-10, 532.1 ± 78.7 pg/mL vs 918.9 ± 63.1 pg/mL). The suppressive effect of gabapentin on pro-inflammatory cytokine expression was partially blocked by the anti-IL-10 antibody [4].Toxicity: No new safety signals or adverse event trends relating to GEn exposure were identified [5]
Company Introduction
Hebei Best Biological Technology Co., Ltd. is a modern advanced enterprise specializing in production and exportation of APIs,Pharmaceutical intermediates, peptides, plant extracts etc. Our products are widely used in medicine, health care products,cosmetics, nutritional supplements and food additives areas.
our factory covers an area of 95 acres, the proposed construction of the plant will be GMP standards, the factory environment clean and tidy, rational layout, with large and medium-sized production workshop and reprocessed shop. It is equipped with advanced equipment quality inspection and research center. Those products of both quality and technical content have reached the domestic advanced level.
Since its establishment, the company has attached great importance to the team training and technical reform. Our modern production equipment guarantees for a fast and effective production with a superior degree of accuracy throughout the whole production line, everything is done in-house, processing,
extraction, packaging and transportation of all links, ensuring maximum quality and efficiency. We are constantly research and development new ingredients and innovative new products, have earned the respect & admiration from the worldwide customers.
After years of continuous development, the company has accumulated rich experience in international trade and customer resources, established a stable customer base and perfect marketing service network. In addition, the company has established long-term technical cooperation with experts and professors from many universities and research institutes in the province. Excellent quality, reasonable price, rapid delivery and good service ensure us to satisfy all kinds of your demands.
If you are interested, please contact me.
Packing&Delivery
Why Choose Us
1. Rich experience
We specialize in this filed for many years, our steriods and hormones exported to all over the world and established long friendly relations of cooperation with them.
2. Great quality,purity and favorable
Good quality is one of our biggest secret to success; you can get the best quality and service from us.
3. Safest and fastest delivery
We have adequate stock so that we can deliver the products with 24 hours as soon as receiving the payment. Fast and discreet shipment will be arranged to pass customs.
4. Good package
Unique ways to ship 10g to 100kg powders to your destination. We offer melting powder into liquid service and ship the liquid in special bottles.
5. Great after-sales service
Any needs or questions contact me freely.
FAQ
Q1: What is your MOQ?
A:Our MOQ is 10g, 100g and 1kg for your evaluation quality of our goods on the condition that sample charge is 100% paid.
Q2: Is there any discount?
A:Yes, for larger quantity, we always support with better price.
Q3: What payment terms do you accept ?
A:We'd like to accept T/T, L/C, Paypal, or Western Union.
Q4: How long will it take to get the goods?
A:Depending on your location, For small order, please expect 5-7 days by DHL, UPS, TNT, FEDEX, EMS. For mass order, please allow 5-8 days by Air, 20-35 days by Sea.
Q5: How do you treat quality complaint?
A: First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
Q6: How can we trust you?
A: You are always warmly welcomed to visit us at any time. Before we start B2B, MIC has audited our company on-spot and approved our credit.
Q7: Do you test all your goods before delivery?
A: Yes, we have 100% test before delivery,International Authorized Third-Party Test for the products if you need are highly welcomed.
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