| CAS: | 6990-06-3 |
| MF: | C31H48O6 |
| MW: | 516.72 |
| EINECS: | 230-256-0 |
| Product Categories: | Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;API;FUCIDINE;antibiotic;Steroids;E-FCell Signaling and Neuroscience;Gene Regulation and Expression;RNA-Protein Translation Inhibitors;Stains and Dyes;Stains&Dyes, A to;6990-06-3 |
| Mol File: | 6990-06-3.mol |
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| Fusidine Chemical Properties |
| Melting point | 190-192°C |
| alpha | D20 -9° (chloroform) |
| Boiling point | 521.49°C (rough estimate) |
| density | 1.0389 (rough estimate) |
| vapor pressure | 0-0Pa at 25℃ |
| refractive index | 1.4890 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Practically insoluble in water, freely soluble in ethanol (96 per cent) |
| form | neat |
| pka | pK: 5.35 in water |
| color | White to Off-White |
| Water Solubility | 2.376-525000μg/L at 25℃ |
| λmax | 204nm(H2O)(lit.) |
| Merck | 14,4317 |
| Stability: | Hygroscopic |
| LogP | 2.68-6.75 at 20℃ |
| CAS DataBase Reference | 6990-06-3(CAS DataBase Reference) |
| Fusidine Usage And Synthesis |
| Mode of action | Fusidic acid forms a stable complex with an elongation factor (EF-G) involved in translocation and with guanosine triphosphate (GTP), which provides energy for the translocation process. One round of translocation occurs, with hydrolysis of GTP, but the fusidic acid–EF-G–GDP complex cannot dissociate from the ribosome, thereby blocking further chain elongation and leaving peptidyl-tRNA in the P site.
Although protein synthesis in Gram-negative bacilli–and, indeed, mammalian cells–is susceptible to fusidic acid, the antibiotic penetrates poorly into these cells and the spectrum of action is virtually restricted to Gram-positive bacteria, notably staphylococci. |
| Chemical Properties | White Solid |
| Uses | antibacterial |
| Uses | Fusidic acid is a bacteriostatic antibiotic. Fusidic Acid suppresses nitric oxide lysis of pancreatic islet cells. Inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA. Dyes and metabolites. |
| Definition | ChEBI: A steroid antibiotic that is isolated from the fermentation broth of Fusidium coccineum. |
| Brand name | Fucidine (Bristol-Myers Squibb). |
| Hazard | Moderately toxic inhibitor of translocation during protein synthesis. |
| Biochem/physiol Actions | Fusidic acid is a tetracyclic triterpenoid with antibiotic activity against Gram-positive bacteria. It is derived from Fusidium coccineum. It shows its activity against anaerobes, corynebacterial, Nocardia, and Neisseria species. Fusidic acid exhibits therapeutic effects against Staphylococcal infections, skin infections. |
Product picture
Packing &shipping&Payment
Packing:25kg/drum
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
| Quantity(Kilograms) | 1 - 10000 | >10000 |
| Est. Time(days) | 5 | To be negotiated |
Company information
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in 4'-Methylacetophenone,Levamisole hydrochloride ,N-Methylformamide and other chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.
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