Name | Fucosterol |
Description | Fucosterol is isolated from E. stolonifera with anti-diabetic, anti-adipogenic and anti-cancer activities. It regulates adipogenesis via modulation of PPARα and C/EBPα expression. |
Cell Research | Cell Line: 3T3-L1 adipocytes. Concentration: 0 μM; 25 μM; 50 μM. Incubation Time: 7 days [1] |
In vitro | Fucosterol (0-50 μM; 7 days) suppresses the expression of PPARα and C/EBPα in fully differentiated control adipocytes [1], shows cytotoxicity against T47D and HT29 cell lines (IC50s: 27.94 and 70.41 μg/ml) [3], and decreases the proliferation of HEK293, MCF-7, and SiHa cells (IC50s: 185.4, 43.3, and 34.0 μg/ml) [4]. |
In vivo | Fucosterol (p.o.; 30mg/kg) causes a significant decrease in serum glucose concentrations and exhibits inhibition of sorbitol accumulations in the lenses [2]. |
Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | Ethanol : 16.67 mg/mL (4.39 mM)
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Keywords | poly ADP ribose polymerase | Inhibitor | inhibit | Endogenous Metabolite | PARP | Fucosterol |
Inhibitors Related | Sucrose | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | Vanillin | Formamide | Glycerol | Thymidine | Naringin | 3-Indoleacetic acid | Oleic acid |
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