| Name | FTY720 (S)-Phosphate |
| Description | FTY720 (S)-Phosphate is the active stereoisomeric phosphate derivative of FTY720 that acts as a potent modulator of sphingosine-1-phosphate (S1P) receptors. FTY720 (S)-Phosphate binds to S1P receptor subtypes S1P1, S1P3, S1P4, and S1P5 with Ki values of 2.1, 5.9, 23, and 2.2 nM respectively, causing receptor internalization on lymphocytes， preventing S1P-mediated lymphocyte egress from lymphoid tissues. FTY720 (S)-Phosphate also enhances endothelial barrier integrity, stimulates transporters such as Abcb1 and Abcc1, and inhibits cytosolic phospholipase A2 activity, highlighting its multifunctional pharmacological properties, making it an compound of interest in the research of diseases including multiple sclerosis, autoimmune diseases and cancer. |
| In vitro | FTY720 (S)-Phosphate (Tys, 1 μM) can preserve the expression level of S1PR1 protein and improve the barrier function of Homo sapiens pulmonary artery endothelial cells by activating S1PR1, without significantly affecting the ubiquitination process of S1PR1 at this concentration. Within the dose range of 0.01-50 μM, FTY720 (S)-Phosphate can inhibit the recruitment of β-arrestin to S1PR1 [1]. |
| In vivo | FTY720 (S)-Phosphate (0.5 mg/kg, intraperitoneal injection) maintained the expression level of S1PR1 in mouse lung tissue, exerted protective effects against bleomycin-induced acute lung injury (ALI), and reduced the degree of leukocyte infiltration in the lung tissue of bleomycin-injured model mice [1]. |
| Storage | The compound is unstable in solution. Please use soon | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 0.5 mg/mL (slightly soluble), Sonication is recommended.
H2O : < 1 mg/mL (insoluble)
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| Keywords | S1PR1 | FTY720P | FTY-720 Phosphate | FTY720 Phosphate | FTY-720 (S)-Phosphate | FTY720 (S)Phosphate | FTY720 (S) Phosphate | FTY 720 Phosphate |
| Inhibitors Related | Fingolimod hydrochloride | LX-2931 | Sphingosine-1-phosphate | ASP-4058 | CAY10444 | Ki16198 | Siponimod | CYM5181 | Poloxamer 407 | MP-A08 | S1PR1 modulator 1 | Ozanimod |
United States
