PRODUCT INFORMATION
| Common Name | Fmoc-amino-PEG3-CH2COOH |
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| CAS Number | 139338-72-0 | Molecular Weight | 429.463 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 651.1±65.0 °C at 760 mmHg |
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| Molecular Formula | C23H27NO7 | Melting Point | 46℃ |
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| MSDS | N/A | Flash Point | 347.6±34.3 °C |
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Use of Fmoc-amino-PEG3-CH2COOH
Fmoc-amino-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
Names
| Name | (3E)-1-(9H-Fluoren-9-yl)-3-hydroxy-2,7,10,13-tetraoxa-4-azapentad ec-3-en-15-oic acid |
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| Synonym | More Synonyms |
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Fmoc-amino-PEG3-CH2COOH Biological Activity
| Description | Fmoc-amino-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
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| Related Catalog | Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker |
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| Target | PEGs Alkyl/ether |
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| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
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| References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 651.1±65.0 °C at 760 mmHg |
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| Melting Point | 46℃ |
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| Molecular Formula | C23H27NO7 |
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| Molecular Weight | 429.463 |
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| Flash Point | 347.6±34.3 °C |
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| Exact Mass | 429.178741 |
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| PSA | 106.81000 |
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| LogP | 2.75 |
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| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
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| Index of Refraction | 1.574 |
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| Storage condition | 2-8°C |
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Precursor & DownStream
| Precursor 9 | Previous 1/3 Next |
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![{2-[2-(2-amino-ethoxy)-ethoxy]-ethoxy}-acetic acid hydrochloride Structure](https://image.chemsrc.com/caspic/417/134978-96-4.png) CAS#:134978-96-4
{2-[2-(2-amino-...
 CAS#:82911-69-1
Fmoc-Osu
 CAS#:134978-99-7
Amino-PEG3-CH2COOH
 CAS#:28920-43-6
9-Fluorenylmeth...
|
| DownStream 0 |
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Synonyms
| FMOC-PHE(3-OH)-OH |
| FMOC-L-M-TYR |
| FMOC-3-HYDROXYL-L-PHENYLALANINE |
| 2-{2-[2-(9-fluorenylmethyloxycarbonylaminoethoxy)ethoxy]ethoxy}acetic acid |
| Fmoc-D-phe(3-OH)-OH |
| 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13-tetraoxa-4-azapentadecan-15-oic acid |
| Fmoc-3-hydroxy-L-Phe |
| 11-(fluoren-9-ylmethyloxycarbonyl)amino-3,6,9-trioxaundecanoic acid |
| (2-{2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy}ethoxy)acetic acid |
| N-FMOC-3-HYDROXY-L-PHENYLALANINE |
| Fmoc-meta-tyrosine |
| 2,7,10,13-Tetraoxa-4-azapentadecan-15-oic acid, 1-(9H-fluoren-9-yl)-3-oxo- |
| Fmoc-11-amino-3,6,9-trioxaundecanoic acid |
| Fmoc-Teg-OH |
| Fmoc-PEG3-acetic acid |
| 5,8,11-Trioxa-2-azatridecanedioic acid 1-(9H-fluoren-9-ylmethyl) ester |
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