| Name | Fluorometholone Acetate |
| Description | Fluorometholone Acetate (Oxylone acetate) is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye. |
| In vitro | Fluorometholone Acetate is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye. [1] |
| In vivo | Hourly topical administration of the drug suspension produces an average reduction of 46.8% in the polymorphonuclear leukocytes invading the corneal stroma. In the cornea, fluorometholone acetate appears to have a greater efficacy, as compared to fluorometholone alcohol, for reducing the number of leukocytes invading that tissue following an inflammatory stimulus. Animal toxicity studies of fluorometholone, including acute intraperitoneal LD50s in mice and rats, subacute oral toxicity in rats and dogs, and subacute topical ocular toxicity in rabbits have demonstrated the safety of this drug for human use. [2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (7.89 mM), Sonication is recommended.
H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 84.00 mg/mL (200.72 mM), Sonication is recommended.
Ethanol : < 1 mg/mL (insoluble or slightly soluble)
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| Keywords | Oxylone Acetate | NSC-47438 | NSC47438 | Inhibitor | inhibit | hCA-II | hCA-I | GlucocorticoidReceptor | Glucocorticoid Receptor | glucocorticoid | Fluorometholone Acetate | Fluorometholone | corticosteroid | Cornea | CarbonicAnhydrase | Carbonic Anhydrase | Carbonate dehydratase | anti-inflammatory |
| Inhibitors Related | Benzenesulfonamide | Hydrocortisone | Cyclamic acid sodium | Mifepristone | Prednisone | Hydrochlorothiazide | Orthanilamide | Dexamethasone acetate | pNNP | Dexamethasone | Prednisone acetate | Corticosterone |
| Related Compound Libraries | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compound Library | ReFRAME Related Library | Anti-Cancer Metabolism Compound Library | Drug Repurposing Compound Library | Inhibitor Library | FDA-Approved Drug Library | Anti-Cancer Approved Drug Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
United States
