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Fisetin (7,3′,4′-flavon-3-ol) is a plant flavonol from the flavonoid group of polyphenols.It can be found in many plants, where it serves as a yellow/ochre colouring agent. It is also found in many fruits and vegetables, such as strawberries, apples, persimmons, onions and cucumbers.Its chemical formula was first described by Austrian chemist Josef Herzig in 1891.
Antioxidant Activity
Fisetin, as a flavonoid is inherently self-contained with antioxidant properties, not only has direct antioxidant activity, but also increases the level of glutathione, the main intracellular antioxidant.
inhibits inflammatory
Fisetin inhibits the NF-κB pro-inflammatory signaling pathway by activating β-catenin protein and silencing the expression of TLR4, which in turn down-regulates the release of inflammatory cytokines and achieves an anti-inflammatory effect.
Boots Long-term Memory
Fisetin, can activate signaling pathways associated with the development of long-term memory in hippocampal slices, activating ERK and inducing phosphorylation of cAMP response element-binding protein (CREB) in rat hippocampal slices. This activation can translate into promoting long-term potentiation (LTP) in hippocampal slices, enhancing long-term synaptic strength in rats, and improving object recognition in mice.
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