名称 | FGI-106 tetrahydrochloride |
描述 | FGI-106 tetrahydrochloride demonstrates potent inhibitory activity across a broad spectrum of viruses, including those causing hemorrhagic fevers such as Ebola, Rift Valley, and Dengue Fever, with half-maximal effective concentrations (EC50s) of 100 nM, 800 nM, and 400-900 nM, respectively. Additionally, it effectively inhibits non-hemorrhagic fever viruses, notably HCV and HIV-1, with EC50s of 200 nM and 150 nM, respectively, indicating its broad-spectrum antiviral potential. |
体外活性 | In cell-based assays, treatment with FGI-106 inhibits viral replication by divergent virus families, including positive and negative-strand RNA viruses.Treatment with 2 μM FGI-106 mediated a 4 log reduction in infectious viral titers relative to matched controls, with an EC90 for inhibition of viral killing of host cells (Vero E6 cells) estimated to be 0.6 μM. |
体内活性 | FGI-106??treatment decreases mortality from Zaire EBOV in a dose-dependent manner. |
存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 7.5 mg/ml (12.41 mM), Sonication is recommended.
|
关键字 | fever | pathogens | Ebola | Influenza Virus | inhibit | HIV-1 | replication | FGI 106 Tetrahydrochloride | HCV | hemorrhagic | Hepatitis C virus | EBOV | HIV | tetrahydrochloride | FGI106 tetrahydrochloride | FGI106 Tetrahydrochloride | Inhibitor | FGI-106 tetrahydrochloride | FGI-106 | broad-spectrum | antiviral | Human immunodeficiency virus | FGI-106 Tetrahydrochloride | lethal | FGI106 | FGI 106 tetrahydrochloride | FGI 106 |
相关产品 | Stavudine | Rifampicin | 5-Fluorouracil | Emtricitabine | Phenytoin sodium | Acetylcysteine | Kaempferol | Dextran sulfate sodium salt (MW 4500-5500) | Lamivudine | Curcumin | Decanedioic acid | Crystal Violet |
相关库 | 经典已知活性库 | 抗病毒库 | 抑制剂库 | 已知活性化合物库 |