| Name | FG 7142 |
| Description | FG 7142 (LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex. FG 7142 , a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM). |
| In vitro | FG-7142 has a high efficacy in modulating GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50 = 137 nM) as compared to the other α subunits.FG-7142 has affinity for those expressing the α subunit, the Ki values are 91 nM; 330 nM; 492 nM and 2.150 μM for α1, α2,α3 and α5 subunits, respectively. |
| In vivo | FG-7142, administered via intraperitoneal injection at doses of 15 mg/kg, enhances tyrosine hydroxylase activity and dopamine turnover specifically in the medial prefrontal cortex and ventral tegmentum, without impacting mesolimbic or nigrostriatal regions. At doses between 15-30 mg/kg, it stimulates mesolimbocortical dopaminergic projections, resulting in elevated dopamine levels in the prefrontal cortex and nucleus accumbens in rats. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 30 mg/mL (133.19 mM)
|
| Keywords | nucleus accumben | inverse agonist | GABA Receptor | LSU 65 | dopaminergic | GABAA receptor | inhibit | Gamma-aminobutyric acid Receptor | FG-7142 | ZK39106 | LSU65 | ZK-39106 | FG 7142 | FG7142 | tyrosine hydroxylase | γ-Aminobutyric acid Receptor | Inhibitor |
| Inhibitors Related | Valproic acid sodium salt | DL-Menthol | β-Alanine | Penicillin G sodium salt | Halothane | Valproic Acid | Chlorothymol | Piperazine citrate | Riluzole | Gabapentin | Nikethamide | (-)-α-Pinene |
| Related Compound Libraries | 经典已知活性库 | 疼痛相关化合物库 | 神经退行性疾病化合物库 | 抗阿尔茨海默症化合物库 | 膜蛋白靶向化合物库 | 抗帕金森病化合物库 | 神经递质受体化合物库 | 已知活性化合物库 | 离子通道库 | 抗癌化合物库 |
United States
