Factory Provide High Quality Anti-Virus CAS 212268-12-7 Favipiravir Powder
Introduction
Product Name : Favipiravir
Other name:Pyrazinecarboxamide, 6-fluoro-3,4-dihydro-3-oxo- (9CI);Favipiravir;Unii-ew5gl2X7E0
CAS No.:259793-96-9
MF:C5H4FN3O2
Purity :99%
MW:157.1
Melting Point :>151°C (dec.)
Density :1.78±0.1 g/cm3(Predicted)
Appearance: white to off white powder
Storage :Sealed in dry,Sealed in dry,Room Temperature
Favipiravir, also known as T705, or Avigan, is a selective inhibitor of viral RNA-dependent RNA polymerase with activity against many RNA viruses, influenza viruses, West Nile virus, foot-and-mouth disease virus as well as other flaviviruses, arenaviruses, bunyaviruses and alphaviruses. Activity against enteroviruses has also been demonstrated. The mechanism of its actions is thought to be related to the selective inhibition of viral RNA-dependent RNA polymerase. Favipiravir does not inhibit RNA or DNA synthesis in mammalian cells and is not toxic to them.
| Item | Specification | Results |
| Appearance | White to light yellow powder. | Conform |
| Identification | The retention time of major peak in the chromatogram of sample solution should correspond to that of the standard solution as obtained in chromatographic assay by HPLC.
| Conform |
| IR spectrum conforms to the standard.
| Conform |
| Water (by KF) | ≤ 0.5% | 0.14% |
| Residue on ignition | ≤ 0.1% | 0.07% |
| Heavy metals | ≤ 20ppm | Conform |
| Chloride | ≤ 0.06% | Conform |
| Melting point | 188 ~ 193ºC | Conform |
| Related substances | Any Single Impurity ≤ 0.05% | 0.01% |
| Total Impurities ≤ 0.5% | 0.03% |
| Assay (on dry basis) | 98.0% ~ 102.0% | 99.96% |
| XRD | Form A | Conforms |
| Particle size | D90 < 50um | 21.48um |
| Microbial test | Total Amount of aerobe ≤ 1000 cfu/g
Yeast & molds ≤ 100 cfu/g
E.Coli: not detected | Conform
Conform
Conform |
| Conclusion | The test results conform to Enterprise Standard. |
Application
Favipiravir can be used for antiviral treatment of influenza a and b. Research shows that, in addition to influenza virus, the drug also showed good antiviral activity against a variety of RNA viruses, such as ebola virus, sand virus, bunya virus, rabies virus..
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