| Name | (E/Z)-Polydatin |
| Description | (E/Z)-Polydatin (Polydatin), is a natural precursor and glycoside form of resveratrol with a monocrystalline structure. While it is isolated from the bark of Picea sitchensis or Polygonum cuspidatum, Polydatin may be detected in grape, peanut, hop cones, red wines, hop pellets, cocoa-containing products, chocolate products and many daily diets. Polydatin possesses anti-inflammatory, immunoregulatory, anti-oxidative and anti-tumor activities. It is shown to mediate a cytotoxic action on colorectal cancer cells by inducing cell arrest and apoptosis. |
| In vitro | In a study involving mice with sepsis induced by cecal ligation and puncture, polydatin (15/45/100 mg/kg) was found to inhibit the production of serum TNF-α and IL-6, the protein expression of lung cyclooxygenase-2 and inducible NO synthase isoforms, and the activation of NF-κB, thereby reducing mortality and lung injury in a dose-dependent manner. The LD50 of polydatin in mice was determined to be 1 g/kg (i.p.). |
| In vivo | Polydatin is a PLA2 inhibitor that reduces the expression of sPLA2-IIA mRNA and the activity of phospholipase A2. It also increases the expression of Clara cell secretory proteins, thereby mitigating lipopolysaccharide-induced lung injury. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 45 mg/mL (115.27 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : < 1 mg/mL (insoluble or slightly soluble)
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| Keywords | inhibit | cuspidatum | Inhibitor | Polygonum | (E/Z) Polydatin | (E/Z)Polydatin | (E/Z)-Polydatin |
| Related Compound Libraries | Bioactive Compound Library | Selected Plant-Sourced Compound Library | Saccharide and Glycoside Natural Product Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library | Natural Product Library for HTS | Anti-Aging Compound Library | Cosmetic Ingredient Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library |
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