名称 | (E/Z)-4-Hydroxytamoxifen |
描述 | (E/Z)-4-Hydroxytamoxifen (Afimoxifene) is a novel estrogen inhibitor, commonly used in research for various estrogen-dependent conditions, including cyclic mastalgia and gynecomastia. |
细胞实验 | Cell lines: Adult Rat and Mouse Cardiac MyocytesConcentrations: 0, 0.5, 1, 3, 5, and 10 μMIncubation Time: 15-45 minMethod:For sarcomere length measurements, cells are covered in Tyrode's containing 4OHT, allowed to reach 36 ± 1°C, and then stimulated at 0.2 Hz. |
动物实验 | Animal Models: Sprague-Dawley ratsFormulation: dissolved in 200 μl tricaprylinDosages: 21 mg/kg, 54 μmol/kgAdministration: oral administration |
体外活性 | 4-OHT is a potent activator of ER and has been shown to have a higher affinity for estrogen receptors compared to tamoxifen. It has significant dose and time-dependent direct effects to alter the contractile function of isolated adult rat cardiac myocytes. 4-HT activates on-target modification frequency for intein-Cas9 variants |
存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 60 mg/mL (154.83 mM) H2O : < 1 mg/mL (insoluble or slightly soluble) Ethanol : < 1 mg/mL (insoluble or slightly soluble)
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关键字 | (E/Z)4Hydroxytamoxifen | Inhibitor | inhibit | (E/Z) 4 Hydroxytamoxifen | Endogenous Metabolite | Estrogen Receptor/ERR | (E/Z)-4-Hydroxytamoxifen |
相关产品 | Kaempferol |
相关库 | 经典已知活性库 | 抗癌临床化合物库 | 药物功能重定位化合物库 | 已知活性化合物库 | 抗癌活性化合物库 | 抗癌药物库 |