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ChemicalBook Product Catalog Exisulind

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Exisulind NEW

$47.00 5mg

$80.00 10mg

$163.00 25mg

Min. Order
Purity98.08%
Cas No59973-80-7
Supply Ability10g
Update time2025-11-10

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

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United States

United States

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Chemical Properties

Product Name	Exisulind
CAS No	59973-80-7
EC-No
Min. Order
Purity	98.08%
Supply Ability	10g
Release date	2025/11/10

Product Introduction

Bioactivity

Name	Exisulind
Description	Exisulind (CP248) induces apoptosis through the activation of protein kinase G (PKG). Exisulind exhibits antineoplastic activity in solid tumour and haematological cancer cell lines and is an inhibitor of tumour growth in rodent models of colon, prostate, bladder, mammary and lung cancer.
In vivo	The topical treatment with NO-Exisulind significantly reduced UVB-induced tumors in SKH-1 hairless mice. The tumors/tumor bearing mouse, the number of tumors/mouse and tumor volume/mouse decreased significantly (P < 0.05) as compared with vehicle-treated and UVB-irradiated positive controls. NO-Exisulind-treated animals showed reduced expression of proliferation markers, such as PCNA and cyclin D1. These mice also manifested increased expression of proapoptotic Bax and decreased expression of antiapoptotic Bcl2 with an increase in the number of TUNEL-positive cells in tumors. NO-Exisulind-treated tumors are less invasive and progress less efficiently from benign to malignant carcinomas[1].
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO : 55 mg/mL (147.69 mM), Sonication is recommended.
Keywords	PKG \| Exisulind \| CP-248 \| CP 248 \| Apoptosis
Inhibitors Related	Stavudine \| Cysteamine hydrochloride \| Sodium 4-phenylbutyrate \| Metronidazole \| Citric Acid Triammonium \| Tributyrin \| L-Methionine \| Sodium citrate \| Cystamine dihydrochloride \| L-Ascorbic acid sodium salt \| Alginic acid \| Dextran sulfate sodium salt (MW 5000)
Related Compound Libraries	Failed Clinical Trials Compound Library \| Bioactive Compound Library \| Membrane Protein-targeted Compound Library \| Kinase Inhibitor Library \| Tyrosine Kinase Inhibitor Library \| Anti-Obesity Compound Library \| Anti-Cancer Clinical Compound Library \| Drug Repurposing Compound Library \| Inhibitor Library \| Bioactive Compounds Library Max \| Anti-Cancer Drug Library \| Anti-Cancer Active Compound Library

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