| 名称 | Etretinate |
| 描述 | Etretinate (Ro 10-9359) is an oral aromatic retinoid acid which is effective in psoriasis and other dermatological syndromes. It activates retinoid receptors, causing an induction of cell differentiation, inhibition of cell proliferation, and inhibition of tissue infiltration by inflammatory cells. |
| 细胞实验 | The HSC-5 cells are plated in 96-well plates at a density of 1.5×103 per 100 μL and used for experiments. Preliminary experiments are performed to determine the effective dose and cytotoxicity of etretinate. The cells are incubated for 72 h with etretinate at concentrations of 5, 10, 25 and 50 nmol⁄L [dissolved in saline containing 0.0001% dimethyl sulfoxide (DMSO)]. The cells are then incubated for a further 2 h with or without 200 μmol⁄L ALA (Sigma). Each plate is then irradiated using a metal halide lamp at doses of 10, 20, 40 and 80 J⁄cm2 (Only for Reference) |
| 体外活性 | K03861 inhibits CDK2 activity by competing with binding of activating cyclins. [1] |
| 体内活性 | There is a significant decrease in mean dermal thickness (P < 0.05) and changes in collagen bundles in the etretinate-treated mice group for a 28-day period compared to control groups. TUNEL assay shows that the density of TUNEL-positive cells in the dermis of etretinate-treated mice for a 14-day period is significantly increased (P < 0.05). The ratio of procollagen α 1 (I) chain to β actin mRNA from etretinate-treated mice for a 1-day period decreased significantly compared to that of the control mice, but the ratio from etretinatetreated mice for a 14-day period increased significantly (P < 0.05)[2]. Etretinate reduces dermal thickness, and suppresses the appearance of skin lesions by inducting apoptosis and perhaps regulation of cytokine expression in MRL/lpr mice[3]. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 65 mg/mL (183.4 mM)
Ethanol : 65 mg/mL (183.4 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)
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| 关键字 | Inhibitor | inhibit | Etretinate | Apoptosis |
| 相关产品 | Stavudine | Sodium 4-phenylbutyrate | Tributyrin |
| 相关库 | 经典已知活性库 | 药物功能重定位化合物库 | 抗癌上市药物库 | FDA 上市药物库 | 已知活性化合物库 | 抗癌药物库 |
United States
