Etrasimod Impurity 13;392-83-6
WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com
Product Code: E063013
English Name: Etrasimod Impurity 13
English Alias: 1-bromo-2-(trifluoromethyl)benzene
CAS No.：392-83-6
Molecular Formula: C₇H₄BrF₃
Molecular Weight: 225.01
Purity Assurance: HPLC ≥99.5%, confirmed by GC-MS and NMR.
Stability: Stable for 36 months at room temperature, with <0.2% degradation in chloroform.
Regulatory Compliance: Complies with USP/EP standards for halogenated impurities.
Residual Solvent Control: Quantifies brominated impurities in Etrasimod via GC-MS.
Synthesis Monitoring: Tracks bromination side reactions during trifluoromethylbenzene synthesis.
Method Validation: Validates GC methods for halogenated compound detection.
This impurity is a potential residual brominating agent or by-product in Etrasimod synthesis. Halogenated impurities require strict control due to potential organ toxicity.
Detection: GC-MS with DB-5MS column and EI source; LOD: 0.1 ppm.
Formation: From excess bromine in trifluoromethylation steps; vacuum distillation reduces content by 90%.
Toxicity: Acute toxicity studies show low oral LD50 in rats; chronic exposure data pending.
NOTE！
We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!
WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com
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