| Name | Ethynodiol diacetate |
| Description | Ethynodiol diacetate (Ethynodiol acetate) is a synthetic progestational hormone utilized alone or combined with estrogens as an oral contraceptive. |
| In vitro | Daily administration of 75 μg of Norgestrel combined with 150 μg of Ethynodiol diacetate and 7.5 μg of Ethinyl estradiol can downregulate plasma concentrations of high-density lipoprotein cholesterol in cynomolgus monkeys. Additionally, a dosage of 6 mg/kg of Ethynodiol diacetate significantly elevates the levels of 3alpha-hydroxy-5alpha-pregnan-20-one and A-homo-3-oxa-5alpha-pregnane-4,20-dione in the urine of female rats, and markedly increases the weight of the rat's pituitary, liver, and kidneys. |
| In vivo | In the presence of an S9 mix, treatment with NDGA inhibits the genotoxic damage induced by Ethynodiol diacetate, which may be attributed to the suppression of cytochrome P450s that prevent the metabolic activation of Ethynodiol diacetate, or due to NDGA's radical scavenging properties. Concurrently, 150 μg/mL Ethynodiol diacetate increases the rate of sister chromatid exchanges and the frequency of chromosomal aberrations in human lymphocytes, and inhibits lymphocyte proliferation. Notably, < 1.5 μM NDGA can reduce the rate of sister chromatid exchanges in human lymphocytes treated with 150 μg/mL Ethynodiol diacetate. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (8.58 mM), Sonication is recommended.
DMSO : 40 mg/mL (104.03 mM), Sonication is recommended.
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| Keywords | progestogenReceptor | progestogen Receptor | ProgesteroneReceptor | Progesterone Receptor | NR3C3 | Inhibitor | inhibit | Ethynodiol Diacetate | Ethynodiol diacetate | Ethynodiol Acetate | Ethynodiol | EstrogenReceptor | Estrogen Receptor | ER |
| Inhibitors Related | Kaempferol | Tamoxifen | Mifepristone | Estradiol | Astragaloside IV | Estradiol benzoate | Progesterone | Melatonin | Allura Red AC | Natamycin | Ethisterone | Estrone |
| Related Compound Libraries | Nuclear Receptor Compound Library | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compound Library | Approved Drug Library | Drug Repurposing Compound Library | Endocrinology-Hormone Compound Library | NO PAINS Compound Library | FDA-Approved Drug Library | Orally Active Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Human Metabolite Library |
United States
