1. Product information
Names
| Name | ethylene glycol bis(2-aminoethyl)tetraacetic acid |
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| Synonym | More Synonyms |
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EGTA Biological Activity
| Description | EGTA is a specific calcium ion chelator. EGTA has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca2+ over Mg2+ (Mg2+ Kd 1-10 mM). EGTA significantly inhibited the substrate adherence capacity of inflammatory macrophages[1][2]. |
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| Related Catalog | Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology |
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| In Vitro | EGTA, proposed as endodontic irrigant, decreases substrate adherence capacity of inflammatory macrophages in a time- and dose-dependent manner. The EGTA concentration that causes an IC50 is 202 mM. Chelators react with calcium ions in the hydroxyapatite crystals to produce a metallic chelate. Removal of calcium ions from the dentine makes the dentinal tissue softer, especially the hydroxyapatite-rich peritubular dentin and increases the diameter of exposed dentinal tubules[2]. |
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| References | [1]. Harris RA, Hanrahan JW. Effects of EGTA on calcium signaling in airway epithelial cells. Am J Physiol. 1994;267(5 Pt 1):C1426-C1434. doi:10.1152/ajpcell.1994.267.5.C1426 [2]. Segura-Egea JJ, Jiménez-Rubio A, Rios-Santos JV, Velasco-Ortega E, Calvo-Gutierrez JR. In vitro inhibitory effect of EGTA on macrophage adhesion: endodontic implications. J Endod. 2003;29(3):211-213. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 678.0±55.0 °C at 760 mmHg |
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| Melting Point | 241 °C (dec.)(lit.) |
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| Molecular Formula | C14H24N2O10 |
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| Molecular Weight | 380.348 |
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| Flash Point | 363.9±31.5 °C |
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| Exact Mass | 380.143097 |
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| PSA | 174.14000 |
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| LogP | -2.53 |
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| Vapour Pressure | 0.0±4.5 mmHg at 25°C |
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| Index of Refraction | 1.547 |
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| Storage condition | Store at RT. |
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| Water Solubility | slightly soluble |
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2. Packaging
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping
4. Contact information
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