| Name | Ethyl 3,4-dihydroxybenzoate |
| Description | Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain. |
| Animal Research | Male Sprague-Dawley rats treated with EDHB (75 mg/kg for 3 days), were subjected to acute HH exposure at 9144 m (30,000 ft) for 5 h. Animals were assessed for transvascular leakage and edema formation in brain and role of key inflammatory markers along with hypoxia responsive genes. |
| In vitro | It is shown that DHB reversibly inhibits both morphological and biochemical differentiation of myoblasts, if it is added to the culture medium before the cell alignment stage.Along with the inhibition of procollagen synthesis, DHB also decreases markedly the production of a collagen-binding glycoprotein (gp46) present in the ER[1]. |
| In vivo | EDHB supplementation effectively scaled down HH induced cerebral edema with concomitant downregulation of brain NF-κB expression.?There was significant curtailment of pro-inflammatory cytokines and cell adhesion molecules.?There was significant downregulation of permeability factor VEGF by EDHB with concomitant increment in hypoxia inducible factor (HIF1α) and anti-inflammatory proteins HO-1 and MT-1 compared to HH control thus accentuating the potential of EDHB as effective hypoxic preconditioning agent in ameliorating HH mediated injury in brain[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (10.98 mM), Sonication is recommended.
DMSO : 22.5 mg/mL (123.51 mM), Sonication is recommended.
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| Keywords | ROS | ReactiveOxygenSpecies | Reactive Oxygen Species | prolyl-hydroxylase | prolyl hydroxylase | NOSynthase | NOS | NO Synthase | Nitric oxide synthases | mitochondrial | Inhibitor | inhibit | Hypoxia-inducible factors | HIFs | HIFProlylHydroxylase | HIF-PH | HIF/HIFProlylHydroxylase | HIF/HIF Prolyl-Hydroxylase | HIF/HIF ProlylHydroxylase | HIF Prolyl-Hydroxylase | HIF ProlylHydroxylase | HIF | Ethyl protocatechuate | Ethyl 3,4-dihydroxybenzoate | Ethyl 3,4dihydroxybenzoate | Ethyl 3,4 dihydroxybenzoate | Autophagy | Apoptosis | antioxidant |
| Inhibitors Related | Stavudine | Aceglutamide | Cysteamine hydrochloride | Sodium 4-phenylbutyrate | Hydroxychloroquine | Guanidine hydrochloride | Tributyrin | Paeonol | Naringin | L-Ascorbic acid sodium salt | Alginic acid | Gefitinib |
| Related Compound Libraries | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Selected Plant-Sourced Compound Library | Miao medicine Compound Library | Natural Product Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Inhibitor Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Bitter Compound library | Bioactive Compounds Library Max | Ancient Chinese Classical Formulas Compound Library |
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