Chemical & Physical Properties:
Name |
| Esomeprazole sodium |
Synonyms |
| 5-Methoxy-2-((S)-((4-methoxy-3,5-dimethyl-2-pyridyl)methyl)sulfinyl-1H-benzimidazole sodium salt |
|
Molecular Structure |
|
|
|
Molecular Formula |
| C17H20N3NaO3S |
Molecular Weight |
| 369.41 |
CAS Registry Number |
| 161796-78-7 |
Esomeprazole is in a group of drugs called proton pump inhibitors. Esomeprazole decreases the amount of acid produced in the stomach.
Esomeprazole is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions involving excessive stomach acid such as Zollinger-Ellison syndrome. Esomeprazole is also used to promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid).
Function
Esomeprazole sodium is used in the treatment of dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, and Zollinger-Ellison syndrome.
Specification
Test items | Specifications | Result |
Appearance | White or slightly coloured powder,slight hygroscopic | almost white powder |
Identification A. IR B.Enantiomeric purity C.Reaction of maganesium D. Water | IR Conforms to the CRS.(2.2.24) Impurity F ≤0.2%(2.2.29) It gives reaction of magnesium(2.3.1) 6.2%~8.0%(2.5.12) | Complies 0.05% Complies 7.3% |
Absorbance | The absorbance is not greater than 0.20 at 440nm.(2.2.25) | 0.12 |
Related substances(HPLC) Impurity E Impurity D Unspecified impurities Total impurity Impurity F | (2.2.29) ≤0.15% ≤0.15% ≤0.10% ≤0.3% ≤0.2%(2.2.29) | 0.04% 0.10% 0.03% 0.2% 0.05% |
Magnesium | 3.30%~3.55% | 3.46% |
Water by K.F. | 6.2%~8.0%(2.5.12) | 7.3% |
Assay(HPLC) | 98.0%~102.0%(2.2.29) | 99.9% |
Residual solvents: a) Acetone b)Ethyl acetate c)Methylene chloride d)Methanol e)Toluene f)Benzene | Not more than 5000ppm Not more than 5000ppm Not more than 100ppm Not more than 3000ppm Not more than 890ppm Not more than 2ppm | 3ppm Not detected Not detected 77ppm Not detected Not detected |
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Company Profile
Hebei Ningnan Trade Co., Ltd. located in Shijiazhuang City, Hebei Province, is a large enterprise specializing in production and R & D. Our company has many years of export experience in this industry and professional logistics distribution.
We have many production lines, including industrial chemicals, pharmaceutical chemicals, chemical raw materials, fine chemicals and customized synthetic products.
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