| In vitro | Eravacycline dihydrochloride is a synthetic antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. It exhibits broad-spectrum activity against gram-negative bacteria, excluding P. aeruginosa, and demonstrates exceptional efficacy against major gram-positive pathogens, including methicillin-resistant S. aureus. Eravacycline also shows potent inhibition of the ribosome. It is effective against 90% of bacterial isolates (MIC90) across various species panels at concentrations from ≤0.008 to 2 μg/mL, except for Pseudomonas aeruginosa and Burkholderia cenocepacia, which have MIC90 values of 32 μg/mL for both. The compound is active against multidrug-resistant organisms, even those exhibiting extended-spectrum β-lactamases and resistance to carbapenems. Notably, eravacycline is a potent agent against A. baumannii, even against strains resistant to sulbactam, imipenem/meropenem, levofloxacin, and amikacin/tobramycin. It outperforms comparative antibiotics from the tetracycline class, levofloxacin, amikacin, tobramycin, and colistin, with MIC50/90 values of 0.5/1 mg/L. Moreover, it inhibits six E. coli strains with MICs ranging from 0.125 to 0.25 mg/L[1]. |
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