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ChemicalBook Product Catalog Eprotirome

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Eprotirome NEW

$95.00 1mg

$238.00 5mg

$353.00 10mg

Min. Order
Purity98.42%
Cas No355129-15-6
Supply Ability10g
Update time2024-11-14

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

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Chemical Properties

Product Name	Eprotirome
CAS No	355129-15-6
EC-No
Min. Order
Purity	98.42%
Supply Ability	10g
Release date	2024/11/14

Product Introduction

Bioactivity

名称	Eprotirome
描述	Eprotirome (KB2115), a synthetic thyroid hormone mimetic, is a thyroid hormone receptor agonist.
动物实验	A catheter was implanted into the right internal jugular vein before the hyperinsulinemic-euglycemic clamp. After recovery, mice were administered GC-1 (0.03 or 0.3 mg/kg), KB2115 (0.3 mg/kg) or T3 (0.06 mg/kg) via intraperitoneal injection for 10 days. On the day of the clamp experiment, conscious, overnight-fasted mice received a primed (10 μCi) and constant rate intravenous infusion (0.1 uCi/min) of [3-3H] glucose to measure basal glucose turnover. After 60–75 minutes of labeled glucose infusion, the hyperinsulinemic-euglycemic clamp was performed with continuous infusion of insulin (12 mU/kg/min) and variable infusion of 25% glucose to maintain euglycemia (~120 mg/dl). Blood samples were collected by tail bleeding (approximately every 10 min) to measure blood glucose concentrations [2].
体内活性	In moderately overweight and hypercholesterolemic subjects Eprotirome (KB2115) was found to be safe and well tolerated and elicited up to a 40% lowering of total and LDL cholesterol after 14 days of treatment. Bile acid synthesis was stimulated without evidence of increased cholesterol production [1]. KB2115 treated mice exhibited increased fasting glucose, although KB2115 did not increase fasting insulin levels [2].
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	Ethanol : 30 mg/mL DMSO : 90 mg/mL (184.75 mM)
关键字	Eprotirome \| THR \| inhibit \| KB 2115 \| Inhibitor \| KB-2115 \| Thyroid Hormone Receptor
相关产品	Propylthiouracil \| Liothyronine \| L-Thyroxine \| L-Thyroxine sodium \| 2,2-BIS(2-HYDROXY-5-BIPHENYLYL)PROPANE \| Resmetirom \| Carbimazole \| Liothyronine sodium \| 2-Thiouracil \| Tiratricol
相关库	表型筛选靶点鉴定库 \| 经典已知活性库 \| ReFRAME 相关化合物库 \| 抗肥胖化合物库 \| 药物功能重定位化合物库 \| 内分泌激素分子库 \| NO PAINS 化合物库 \| 临床期小分子药物库 \| 已知活性化合物库 \| 抗代谢疾病化合物库

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