Ellagic acid NEW

Product Description

Ellagic acid is an organic substance with a chemical formula of C14H6O8, a polyphenol dilactone, and a dimeric derivative of gallic acid. Ellagic acid is a natural polyphenol component widely found in various soft fruits, nuts and other plant tissues. The color reaction between ellagic acid and ferric chloride is blue, and yellow when it meets sulfuric acid.
Ellagic acid exhibits a significant inhibitory effect on chemical substances-induced carcinogenesis and many other carcinogenesis, especially colon cancer, esophageal cancer, liver cancer, lung cancer, tongue and skin tumors and so on.
Ellagic acid can not only exist in free form, but also in condensed form (such as ellagitannin, glycosides, etc.) in nature. The color reaction of ellagic acid and ferric chloride is blue, and it is yellow when it meets sulfuric acid. The Greiss-meger reaction is positive, and it is easy to combine with metal cations such as Ca2 and M. Pure ellagic acid is a yellow needle-like crystal with a melting point (pyridine) greater than 360 ºC. It is slightly soluble in water and alcohol, soluble in alkali, pyridine and dimethyl sulfoxide, and insoluble in ether.It is also one of the effective whitening ingredients recognized by dermatology medicine. At the same time, it is a kind of polyphenol molecule, which is widely present in many kinds of plants and fruits in nature. Used to whiten skin, inhibit tyrosinase activity, block melanin production, and have whitening and spot-lightening effects. In addition, ellagic acid can effectively protect from external damage. Blocks the activity of tyrosinase, inhibits the production of melanin, and has an antioxidant effect. That is to say, it is excellent in blocking the melanin pigment production reaction in melanin producing cells, and has an antioxidant effect.

FUNCTION

1. Scavenging free radicals
Since the 1950s, the antioxidant properties of ellagic acid in the human body and in vitro have been continuously explored and studied, and more and more research results have shown that ellagic acid has strong free radical scavenging and antioxidant capabilities. Ellagic acid has a scavenging effect on oxygen free radicals and hydroxyl free radicals, and its ability to scavenge free radicals is higher than that of antioxidants such as sesamol, olive leaf extract and lutein.

2. Inhibit lipid peroxidation
In inhibiting lipid peroxidation, ellagic acid is considered to be the most effective inhibitor of the initial stage of microsomal NADPH-dependent lipid peroxidation. Ellagic acid can also strongly inhibit the lipid peroxidation induced by adriamycin. . Ellagic acid inhibits iron myoglobin/hydrogen peroxide-dependent lipid peroxidation. Ellagic acid can prevent lipid peroxides (LPO) caused by exogenous substances in T cells, inhibit the production of reactive oxygen species (ROS), and improve cell death caused by cytotoxins.

3. Other antioxidant activities
Ellagic acid can reduce the cell damage caused by radiation, hydrogen peroxide and mitomycin C in mouse bone marrow cells. Ellagic acid effectively inhibits the oxidation of DCDHF induced by peroxynitrite and the oxidation of peroxynitrite itself. At the same time, ellagic acid prevents the single-strand break of pTZ 18U plasmid DNA induced by peroxynitrite and the nitration of tyrosyl groups in calf serum albumin. Therefore, in vitro, ellagic acid protects biomolecules from oxidative and nitrifying damage caused by peroxynitrite.

4.The activation of pancreatic astrocytes is an important cause of pancreatic fibrosis, acute pancreatitis and other diseases. Ellagic acid inhibits the activity of activin-1 and mitogen-activated protein kinase induced by interleukin 1b (IL-1) and tumor necrosis factor-α (TNF-α), thereby inhibiting the transformation of new pancreatic astrocytes It is an activated fibrous phenotype. As a secondary metabolite, ellagic acid plays a role in anti-eosinophilic activity in the β-glucan peritonitis model. Ellagic acid is an effective inhibitor of eosinophils and can be used to treat allergic inflammation. Ellagic acid can resist carbon tetrachloride-induced liver poisoning in vivo and in vitro, and it can also resist lipid peroxidation induced by tert-butyl hydroperoxide, so it has the effect of protecting the liver.

5.Melanocytes exist in the basal layer of the epidermis, where melanin is produced. The raw material for melanin production is tyrosine (tyrosine), and tyrosine must be converted into dopa (DOPA) and dopaquinine (DOPAquinine) by tyrosinase, and finally melanin (melanin) is formed. Ellagic acid blocks the production of melanin by inhibiting the activity of tyrosinase.Therefore, high-purity ellagic acid is mainly used as an additive in medicines, health foods and cosmetics, as functional factors such as anti-oxidation, suppression of human immunodeficiency virus, and skin whitening.