| 名称 | Echinatin |
| 描述 | Echinatin (Retrochalcone) is extracted from licorice and is a natural chalcone. Echinatin has a wide range of biological activities including hepatoprotective, anti-inflammatory, anti-bacterial infections, and attenuates lung damage. |
| 体外活性 | METHODS: Esophageal squamous cell carcinoma cells KYSE30 and KYSE270 were treated with Echinatin (10-40 µM) for 1-5 days and cell viability was measured by CCK-8 assay.
RESULTS: Echinatin significantly inhibited cell proliferation in a dose- and time-dependent manner. [1]
METHODS: Human osteosarcoma cells 143B and MG63 were treated with Echinatin (30-50 µM) for 24 h. Cell cycle was measured by Flow cytometry.
RESULTS: Echinatin significantly increased the percentage of osteosarcoma cells in the S phase of the cell cycle. [2] |
| 体内活性 | METHODS: To test the antitumor activity in vivo, Echinatin (20-50 mg/kg) was administered by gavage to nude mice bearing KYSE270 xenografts every two days for 14 days.
RESULTS: Tumor load was significantly suppressed, with a 57% and 48% reduction in the groups treated with 20 and 50 mg/kg Echinatin, respectively.Echinatin inhibited the AKT/mTOR pathway, as evidenced by a reduction in the expression levels of p-AKT and p-mTOR. [1] |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4.9 mg/mL (18.13 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.
Chloroform : Soluble
DMSO : 20 mg/mL (74 mM)
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| 关键字 | inhibit | Echinatin | Inhibitor |
| 相关产品 | Tempo | Cycloolivil | Sodium 4-aminosalicylate dihydrate | Rubiadin | Edaravone | AFMK | Maclurin | Retusin | Peonidin-3-O-glucoside chloride | Isomangiferin | Rebamipide | Cyclo(L-Phe-L-Pro) |
| 相关库 | 黄酮类天然产物库 | 经典已知活性库 | 中药单体化合物库 | 植物来源化合物库 | 中药抗炎分子库 | 高通量筛选天然产物库 | 抗衰老化合物库 | 已知活性化合物库 | 古代经典名方目录分子库 | 药食同源库 |
United States
