| 名称 | E3330 |
| 描述 | E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity. |
| 细胞实验 | PANC1 cells are placed in one well of a 12-well plate and treated with 5 to 30 μM E3330. After a 24, 48, and 72 h of culture, the cells are washed with PBS and stained with trypan blue, and cell viability is examined by counting the live cell numbers.(Only for Reference) |
| 体外活性 | E3330 affects hemangioblast development in vitro via inhibition of Ape1 redox activity. [1] E3330 inhibits the growth of human pancreatic cancer cell line PANC1, XPA1, MIAPACA, BxPC3, and PK9. E3330 also promotes exit of cell cycle in PANC1 cells, inhibits the DNA-Binding activity of HIF-1α and migration of pancreatic cancer cells. [2] In JHH6 cells, E3330 prevents the functional activation of NF-κB via the alteration of APE1 subcellular trafficking and reduces IL-6 and IL-8 expression induced by TNF-α and FAs accumulation through blockage of the redox-mediated activation of NF-κB. [3] |
| 体内活性 | In mice with endotoxin-mediated hepatitis, E3330 (300 mg/kg, p.o.) attenuates the elevation of plasma tumor necrosis factor activity and protectes mice from liver injury. [4] In Rat model, E3330 (100 mg/kg, p.o.) also protectes rats from severe liver injury induced with endotoxin plus galactosamine. [5] |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 50 mg/mL (132.11 mM), Sonication is recommended.
H2O : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : 70 mg/mL (185 mM)
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| 关键字 | pancreatic cancer | TNF-α | REF-1 | NF-κB | HIFs | Inhibitor | HIF-PH | Nuclear factor-kappaB | APX-3330 | APE1 | APX 3330 | NSCLC cells | neuroprotective | APX3330 | E-3330 | endonuclease | VEGFR | EPCs | AP-1 | HUVECs | Nuclear factor-κB | Reactive Oxygen Species | E 3330 | E3330 | DNA-binding | Activator Protein 1 | DNA/RNA Synthesis | Hypoxia-inducible factors | orally | PANC1 | HIF/HIF Prolyl-Hydroxylase | anticancer | H1975 | PCECs | inhibit | IL-8 | Vascular endothelial growth factor receptor |
| 相关产品 | Rifampicin | 5-Fluorouracil | Ribavirin | Guanidine hydrochloride | 2,4-D | Resveratrol | Glucosamine | Hydroxycitric acid tripotassium hydrate | Acyclovir | Thymidine | Temozolomide | Folic acid |
| 相关库 | DNA 损伤和修复分子库 | 经典已知活性库 | ReFRAME 相关化合物库 | 抗癌临床化合物库 | 药物功能重定位化合物库 | 抑制剂库 | 抗衰老化合物库 | 已知活性化合物库 | 抗癌药物库 | 抗癌活性化合物库 |
United States
