PRODUCT INFORMATION
| Common Name | Dynorphin A (1-13) |
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| CAS Number | 72957-38-1 | Molecular Weight | 1603.955 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A |
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| Molecular Formula | C75H126N24O15 | Melting Point | N/A |
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| MSDS | ChineseUSA | Flash Point | N/A |
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Use of Dynorphin A (1-13)
Porcine dynorphin A (1-13) is a potent, endogenous κ opioid receptor agonist and is antinociceptive at physiological concentrations. Sequence: Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys. |
Properties
Articles29
Spectrum
Names
| Name | Dynorphin A (1-13) |
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| Synonym | More Synonyms |
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Dynorphin A (1-13) Biological Activity
| Description | Porcine dynorphin A (1-13) is a potent, endogenous κ opioid receptor agonist and is antinociceptive at physiological concentrations. Sequence: Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys. |
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| Related Catalog | Signaling Pathways >> Others >> Others Research Areas >> Others Peptides |
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| Target | Κ opioid receptor[1]. |
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| In Vivo | Dynorphin A (1-13) exposure (33 μM) causes a significant loss in neuronal viability at 4 h with a visible destruction in neuronal morphology seen at 16 h. Exposure to dynorphin A (1-13) causes acute increases in [Ca2+]i in individual neurons similar to increases seen with acute NMDA treatment. Continuous exposure to dynorphin A (1-13) (100 μM) causes a significant loss of neurons over time[1]. |
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| References | [1]. Hauser KF, et al. Dynorphin A (1-13) neurotoxicity in vitro: opioid and non-opioid mechanisms in mouse spinal cord neurons. Exp Neurol. 1999 Dec;160(2):361-75. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Molecular Formula | C75H126N24O15 |
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| Molecular Weight | 1603.955 |
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| Exact Mass | 1602.983398 |
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| PSA | 661.70000 |
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| LogP | -0.50 |
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| Index of Refraction | 1.645 |
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| Storage condition | -20°C |
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MSDS
Dynorphin A (1-13) MSDS(Chinese) |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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