Name | DPTN dihydrochloride |
Description | DPTN dihydrochloride is a potent and selective A3AR antagonist with Ki values of 1.65, 9.61 and 8.53 nM in human, mouse and rat, respectively. |
In vitro | DPTN dihydrochloride is a potent antagonist of human, mouse, and rat A3AR. However, compared with human A3AR, DPTN dihydrochloride has a weaker effect and reduced selectivity in mice and rats (approximately 20 times that of A2BAR).[1]
The binding affinity test of DNPT (10 μM) on the cell membrane of transfected HEK293 cells showed that its Ki values for hA1, hA2A, hA2B and hA3 were 162±49, 121±42, 230±40 and 1.65±0.57 nM respectively[ 1]. The Ki values of DPTN dihydrochloride at A1, A2A, A2B and A3 receptors are 411, 830, 189 and 9.61 nM (mouse); 333, 1147, 163 and 8.53 nM (rat) respectively.[1] |
Storage | Shipping with blue ice. |
Solubility Information | DMSO : 2.30 mg/mL (5 mM), Sonication is recommended.
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Keywords | DPTN Dihydrochloride | DPTN | DPTNdihydrochloride |
Inhibitors Related | Theophylline monohydrate | Diphylline | Acefylline | Aminophylline | Inosine | Theobromine | Istradefylline | Theophylline | Adenosine antagonist-1 | Doxofylline |
Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | GPCR Compound Library |