| Name | DPCPX |
| Description | DPCPX is a highly selective, high-affinity antagonist radioligand for the A1 adenosine receptor, a xanthine derivative with a Ki of 0.45 nM at the A1 receptor and over 700-fold selectivity versus the A2 subtype. It demonstrates robust brain penetration, reaching brain concentrations of 0.8% of the injected dose per gram within five minutes, with a heterogeneous distribution peaking in the cerebellum and hippocampus. Researchers rely on DPCPX as a standard probe for ex vivo and in vivo localization of A1 receptors, as well as for electrophysiology studies examining purinergic control of hippocampal excitability. |
| In vivo | DPCPX, a selective adenosine A1 receptor antagonist, enhances the antidepressant-like effects of imipramine, escitalopram, and reboxetine in mice behavioral tests |
| Storage | Keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : < 1 mg/mL (insoluble or slightly soluble)
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1.06 mg/mL (3.48 mM), Solution.
10% DMSO+90% Saline : < 1.06 mg/mL (3.48 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.
DMSO : 10.6 mg/mL (34.82 mM), Sonication is recommended.
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| Keywords | PD-116948 | PD116948 | P1 receptor | Inhibitor | inhibit | DPCPX | AdenosineReceptor | Adenosine Receptor | A1 |
| Inhibitors Related | Xanthine | Theophylline monohydrate | Diphylline | Adenosine monophosphate | Acefylline | Sulcatone | Adenosine 5'-monophosphate monohydrate | Inosine | Theobromine | Adenosine 5'-monophosphate disodium salt | Theophylline | Doxofylline |
| Related Compound Libraries | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | ReFRAME Related Library | Bioactive Compound Library | Neurotransmitter Receptor Compound Library | Inhibitor Library | NO PAINS Compound Library | GPCR Compound Library | Anti-Cancer Compound Library |
United States
