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ChemicalBook Product Catalog DIM-C-pPhCO2Me

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DIM-C-pPhCO2Me NEW

$30.00 5mg

$50.00 10mg

$98.00 25mg

Min. Order
Purity99.86%
Cas No151358-48-4
Supply Ability10g
Update time2025-11-09

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

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United States

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Chemical Properties

Product Name	DIM-C-pPhCO2Me
CAS No	151358-48-4
EC-No
Min. Order
Purity	99.86%
Supply Ability	10g
Release date	2025/11/09

Product Introduction

Bioactivity

Name	DIM-C-pPhCO2Me
Description	DIM-C-pPhCO2Me is an antagonist of nuclear receptor 4A1 (NR4A1).
Cell Research	Knockdown of NR4A1 in ACHN and 786-O cells was carried out using Lipofectamine 2000 reagent according to the manufacturer's protocol. siRNA complexes used in the study are as follows: siGL2-5', CGU ACG CGG AAU ACU UCG A; siNR4A1 (1)-SASI_Hs02_00333289; siNR4A1 (2)-SASI_Hs01_00182072. ACHN RCC cells were plated on 12-well plates at 5 x 104 cells per well in DMEM supplemented with 2.5% charcoal-stripped FBS. After 24 hr, various amounts of DNA [NBRE3-luc (400 ng), FLAG-NR4A1 (40 ng)] were cotransfected into each well by Lipofectamine 2000 reagent according to the manufacturer's protocol. After 6 hr of transfection, cells were treated with 2.5% stripped DMEM containing either DMSO, DIM-C-pPhOH (20 μM) or DIM-C-pPhCO2Me (15 μM) for 18 hr [1].
In vitro	DIM-C-pPhCO2Me inhibited growth and induced apoptosis in ACHN and 786-O cells [1]. DIM-C-pPhCO2Me decreased NR4A1-dependent transactivation in RMS cells and inhibited RMS cell and tumor growth and induced apoptosis. Both NR4A1 knockdown and treatment with DIM-C-pPhCO2Me also induced ROS which activated stress genes and induced sestrin 2 which activated AMPK and inhibited mTOR in the mutant p53 RMS cells [2].
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (5.26 mM), Sonication is recommended. DMSO : 50 mg/mL (131.43 mM), Sonication is recommended.
Keywords	NR4A1 \| Inhibitor \| inhibit \| DIM-C-pPhCO-2Me \| DIM-C-pPhCO2Me \| DIMCpPhCO2Me \| DIM C pPhCO2Me
Inhibitors Related	Teduglutide \| Cytosporone B \| TMPA \| Broussochalcone A \| DIM-C-pPhOCH3 \| DIM-C-pPhOH \| 4-PQBH \| Nur77 modulator 1
Related Compound Libraries	Nuclear Receptor Compound Library \| Apoptosis Compound Library \| Bioactive Compound Library \| Inhibitor Library \| NO PAINS Compound Library \| Bioactive Compounds Library Max \| Anti-Cancer Compound Library \| Anti-COVID-19 Compound Library \| Anti-Cancer Active Compound Library

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