**Dihexa (Nootropic Dipeptide): A Comprehensive Overview**
**Definition:**
Dihexa, also known as Nootropic Dipeptide, is a synthetic peptide with the chemical name Hexanoyl-Tyr-Ile-Ahx-NH2. It has a CAS number of 1401708-83-5 and a molecular formula of C27H44N4O5. This compound is characterized as a white to off-white powder with a purity of ≥98% and is stored under sealed, light-protected conditions at 2-8°C.
**Function:**
Dihexa is an orally active, blood-brain barrier-permeable angiotensin IV analog. It exhibits high affinity for hepatocyte growth factor (HGF), with a Kd value of 65 pM, and enhances HGF-dependent c-Met receptor activation. This mechanism underlies its potential to improve cognitive function and exhibit antipsychotic activity in animal models.
**Applications:**
1. **Cognitive Enhancement:** Dihexa has shown promise in improving memory and cognitive function, making it a candidate for research in neurodegenerative diseases like Alzheimer's.
2. **Psychiatric Research:** Its antipsychotic properties are being explored for potential therapeutic applications in mental health disorders.
3. **Scientific Research:** Dihexa is widely used in biochemical and pharmaceutical research due to its unique mechanism of action and potential medical applications.
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