Pharmacodynamic
ethamizine citrate (DEC) is effective on the adult of Nematodes networt of cattle and sheep, and has a good effect on the larvae and strongylodes, and has a certain effect on metastrongylodes of pigs. This product has high activity against difilaria Canis in vivo. At present, the mechanism of anti-filarial and anti-nematode action of this product is not completely clear, but it can be determined that it acts on the nervous system of the parasite in the form of nicotine to paralyze the parasite body
Pharmacokinetics:
This product is easily absorbed from the digestive tract after internal administration, and reaches the peak concentration in blood 3 hours after administration, and then the plasma drug can be detected for about 48 hours. The drug is widely distributed in the body tissues and is metabolized in the liver by N-dealkylation and N-oxidation. This product is excreted in urine in its original form or as N-oxidation metabolites. 70% of the dose is excreted within 24 hours, of which 10% to 25% is excreted in its original form.
China
