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ChemicalBook Product Catalog Dicirenone

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Dicirenone NEW

$700.00 1mg

$1800.00 5mg

Min. Order
Purity99.1%
Cas No41020-79-5
Supply Ability10g
Update time2024-11-20

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

3YR

United States

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Chemical Properties

Product Name	Dicirenone
CAS No	41020-79-5
EC-No
Min. Order
Purity	99.1%
Supply Ability	10g
Release date	2024/11/20

Product Introduction

Bioactivity

Name	Dicirenone
Description	Dicirenone (SC26304) inhibits the Mineralocorticoid receptor (MR), aldosterone regulation of the urinary K+:Na+ ratio, and aldosterone binding to renal cytoplasmic and nuclear receptors.
In vivo	In glycerol density gradients, cytoplasmic [3H]Aldosterone receptor complexes sediment at 8.5 S and 4 S in low concentrations of salt and at 4.5 S in high concentrations of salt. Similarly, cytoplasmic [3H]Dicirenone receptor complexes sediment at 3 S in low concentrations of salt and 4 S in high concentrations of salt. The cytoplasmic binding of [3H]Aldosterone and [3H]Dicirenone is similar in magnitude and involves the same set of sites. Under three sets of conditions - (i) in the intact rat, (ii) in kidney slices, and (iii) in reconstitution studies (mixing prelabeled cytoplasm with either purified renal nuclei or chromatin) - [3H]Dicirenone does not yield specific nuclear complexes, in contrast to the reproducible generation of these complexes with [3H]Aldosterone. Administration of Dicirenone (SC-26304) alone in doses of 3-600 μg/100 g of body weight has no effect on urinary Na+:creatinine or K+:creatinine ratios, expressed as urinary K+:Na+ ratios. Aldosterone (0.3 μg/100 g of body weight) increases the K+:Na+ ratio 5-fold. This increase is significantly inhibited by 180 μg/100 g of body weight of Dicirenone and completely inhibited by 600 μg/100 g of body weight. To correlate inhibitory action and receptor occupancy, the same doses of Dicirenone are given to rats injected with 0.036 μg of [3H]Aldosterone. A dose of 180 μg/100 g of body weight reduces specific binding of Aldosterone in cytoplasmic and nuclear fractions to less than half of the control levels, and 600 μg/100 g of body weight eliminates specific binding. The dose of Aldosterone used in the physiological studies is about eight times that used in the binding studies, but both doses are well below saturating amounts[1].
Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Keywords	Dicirenone \| SC 26304 \| SC-26304
Inhibitors Related	Nimodipine \| Hydrocortisone \| Sodium oleate \| Mifepristone \| Dexamethasone acetate \| trans-Aconitic acid \| Prednisone acetate \| Desonide \| Revaprazan hydrochloride \| Corticosterone

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