| Name | Dichlorophen |
| Description | Dichlorophen (DDM) is a nontoxic laxative vermicide of chlorinated phenol compound. Dichlorophen is used as a veterinary fungicide, anthelmintic, and anti-protozoan, as well as an ingredient in antimicrobial soaps and shampoos. This agent probably acts by increasing the clearing of intestinal contents, thereby eradicating tapeworm infections from the intestines. |
| Kinase Assay | Effect of inhibition of Acetaminophen on COX-1 and COX-2 activity in human whole blood: For COX-1 assay, aliquots of human whole blood drawn from healthy volunteers without anticoagulant are transferred to glass tubes containing Acetaminophen or DMSO, serum is separated by centrifugation after clotting, and serum TxB2 levels are determined. For COX-2 assay, aliquots of heparinized whole blood are incubated with LPS (10 μg/mL) and aspirin (10 μg/mL), plus Acetaminophen or DMSO for 24 hours at 37 °C, plasma is separated by centrifugation, and PGE2 levels are determined subsequently. The degree of COX-1 or COX-2 inhibition is calculated as the percentage change of plasma eicosanoid (TxB2 for COX-1 and PGE2 for COX-2).Concentration response curves are fitted by a sigmoidal regression with variable slope for both enzymatic assays, and the 50% inhibitory concentration (IC50) values are derived by using of PRISM Version 3.0. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 45 mg/mL (167.21 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (7.43 mM), Sonication is recommended.
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| Keywords | Parasite | Inhibitor | inhibit | Fungal | Dichlorophen | Bacterial |
| Inhibitors Related | Neomycin sulfate | Calcium Propionate | Levulinic acid | D(+)-Raffinose pentahydrate | Benzyl propionate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Hydroxychloroquine | Fenpyroximate | Dimethyl sulfoxide | Sodium diacetate | BES |
| Related Compound Libraries | Pesticide Compound Library | Anti-Parasitic Compound Library | Bioactive Compound Library | ReFRAME Related Library | Anti-Fungal Compound Library | NO PAINS Compound Library | Anti-Bacterial Compound Library | Cosmetic Ingredient Compound Library | Bioactive Compounds Library Max | Anti-Infection Compound Library | Anti-Gram-Positive Bacterial Library | Human Metabolite Library |
United States
