| Di-tert-butyl Chloromethyl Phosphate Basic information |
| Product Name: | Di-tert-butyl Chloromethyl Phosphate |
| Synonyms: | Di-tert-butyl Chloromethyl Phosphate;PHOSPHORIC ACI DI-T-BUTYL EXTER CHLOROMETHYL ESTER;Phosphoric acid, chloroMethyl bis(1,1-diMethylethyl) ester;Phosphoric acid di-tert-butyl chloromethyl ester;Chloromethyl di-tert-butyl phosphate;Phosphoric acid ditert-butyl ester chloromethyl ester;Di-tert-butyl (chloromethyl) phosphate (stabilized with potassium carbonate);Fostemsavir-SM |
| CAS: | 229625-50-7 |
| MF: | C9H20ClO4P |
| MW: | 258.68 |
| EINECS: |
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| Product Categories: | intermediates;SiChem |
| Mol File: | 229625-50-7.mol |
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| Di-tert-butyl Chloromethyl Phosphate Chemical Properties |
| Boiling point | 272.9±23.0 °C(Predicted) |
| density | 1.115±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Benzene (Slightly), Methanol (Slightly) |
| form | clear liquid |
| color | Colorless to Light yellow |
| Stability: | Moisture Sensitive |
| InChI | InChI=1S/C9H20ClO4P/c1-8(2,3)13-15(11,12-7-10)14-9(4,5)6/h7H2,1-6H3 |
| InChIKey | LNJAJHJFSKUCIR-UHFFFAOYSA-N |
| SMILES | P(OC(C)(C)C)(OC(C)(C)C)(OCCl)=O |
| CAS DataBase Reference | 229625-50-7 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22 |
| Safety Statements | 36/37 |
| HS Code | 29199000 |
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| Di-tert-butyl Chloromethyl Phosphate Usage And Synthesis |
| Description | Di-tert-butyl (chloromethyl) phosphate has become one of the most common reagents to prepare phosphon-oxymethyl pro-drugs, generally by direct alkylation of hydroxyl or amino groups. Its synthesis was first reported in 1999 via a reaction of di-tert-butyl tetramethylammonium phosphate with chloroiodomethane. This approach required the use of the corresponding tetramethylammonium phosphate and a vast excess (>11 equiv) of chloroiodomethane to minimize the formation of tetra-tert-butyl methylene bisphosphate[1]. |
| Uses | Used as an intermediate for laboratory research. |
| Synthesis | Di-tert-butyl (chloromethyl) phosphate, a key compound in the formation of many phosphon-oxymethyl pro-drugs, is prepared by reacting chloromethyl chlorosulfate (CMCS) with di-tert-butyl potassium phosphate (DTBPP) . |
| References | [1] Bin Zheng*. “Development of Efficient Processes for the Preparation of Di-tert-butyl Potassium Phosphate and Di-tert-butyl (Chloromethyl) Phosphate.” Organic Process Research & Development 18 5 (2014): 636–642. |
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| Di-tert-butyl Chloromethyl Phosphate Preparation Products And Raw materials |
| Raw materials | Methanaminium, N,N,N-trimethyl-, bis(1,1-dimethylethyl) phosphate (1:1)-->Chloromethyl chlorosulfate-->DI-T-BUTYL PHOSPHORIC ACID-->DI-TERT-BUTYLPHOSPHATE, TETRABUTYLAMMONIUM SALT-->Chloromethanesulfonyl chloride-->DI-TERT-BUTYL PHOSPHITE-->Potassium di-tert-butyl phosphate-->Dibenzyl phosphate |
Product picture
Packing &shipping&Payment
Packing:25kg/drum
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
| Quantity(Kilograms) | 1 - 10000 | >10000 |
| Est. Time(days) | 5 | To be negotiated |
Company information
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in 4'-Methylacetophenone,Levamisole hydrochloride ,N-Methylformamide and other chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.
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