Chinese name: Desherilin
English name: Deslorelin
CAS: 57773-65-6
Molecular formula: C64H83N17O12
MDL number: MFCD00167401
Molecular weight: 1282.45
Appearance: white powder. The biological activity is dozens of times stronger than that of natural LH-RH.
Melting point: >189oC
Specific rotation: D24-61 ° (c = 0.37 in 0.1M acetic acid)
Density: 1.48± 0.1g /cm3(Predicted)
Storage condition: −20°C
Solubility: acetic acid (slightly soluble), DMSO (slightly soluble), methanol (slightly soluble)
Predicted Acidity coefficient (pKa) : 9.82±0.15
Form: solid
Color: White to off-white
Sequence: Pyr-His-Trp-Ser-Tyr-DTrp-Leu-Arg-Pro-NHEt
InChIKey: GJKXGJCSJWBJEZ-QCOVUDKBNA-N
use
Biochemical research; It is clinically used to treat prostate cancer
Preparation method
The corresponding protective amino acid monomer was used as raw material to synthesize by solid-phase or liquid-phase synthesis.