| Name | Deoxyandrographolide |
| Description | Deoxyandrographolide (14-deoxyandrographolide) potentiates NGF-induced neurite outgrowth. Deoxyandrographolide suppresses the production of proinflammatory mediators TNF-α and IL-6. |
| In vitro | Treatment with 14-deoxyandrographolide (14-DAG) activated AMPK through induction of cyclic AMP-protein kinase A pathway [1]. 14-DAG down-regulated the formation of a death-inducing signaling complex, resulting in the desensitization of hepatocytes to TNF-alpha-induced apoptosis. Pretreatment of hepatocytes with 14-DAG accentuated microsomal Ca-ATPase activity through induction of NO/cGMP pathway [2]. 14-DAG, in concentrations between 10-100 μM, reduced the extracellular acidification rate and the intracellular alkalinization in a dose-dependent manner. In addition, 14-DAG reduced PAF-induced calcium flux in the presence of extracellular calcium, and tyrosine phosphorylation of a 44 kDa protein corresponding to the MAPK(ERK1) [3]. |
| In vivo | The protective effect of 14-DAG against ethanol-induced hepatic injury is based on its ability to reduce oxidative stress through cNOS dependent improvement of redox status. 14-DAG mediated activation of adenylate cyclase-cAMP signaling leading to the up-regulation of cNOS may provide a promising approach in the prevention of liver diseases during chronic alcoholism [4]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 10 mg/mL (29.9 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (2.99 mM), Sonication is recommended.
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| Keywords | TNF-α | proinflammatory | outgrowth | neurite | mRNA | mediators | LPS | levels | ILReceptor | IL-6 | IL Receptor | Deoxyandrographolide |
| Inhibitors Related | Kaolin | Ethyl palmitate | Gum arabic | D(+)-Raffinose pentahydrate | Lactose | Triphenyl phosphate | 1,8-Cineole | 1,4-Naphthoquinone | Tributyrin | Glucosamine | Gluconate Calcium | Magnesium sulfate |
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