Basic information Safety Related Supplier

ChemicalBook Product Catalog Biochemical Engineering Plant extracts Deoxyandrographolide

1/1

Deoxyandrographolide NEW

$73.00 1mg

$166.00 5mg

$247.00 10mg

Min. Order
Purity99.67%
Cas No79233-15-1
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

3YR

United States

show more

Chemical Properties

Product Name	Deoxyandrographolide
CAS No	79233-15-1
EC-No
Min. Order
Purity	99.67%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	Deoxyandrographolide
Description	Deoxyandrographolide (14-deoxyandrographolide) potentiates NGF-induced neurite outgrowth. Deoxyandrographolide suppresses the production of proinflammatory mediators TNF-α and IL-6.
In vitro	Treatment with 14-deoxyandrographolide (14-DAG) activated AMPK through induction of cyclic AMP-protein kinase A pathway [1]. 14-DAG down-regulated the formation of a death-inducing signaling complex, resulting in the desensitization of hepatocytes to TNF-alpha-induced apoptosis. Pretreatment of hepatocytes with 14-DAG accentuated microsomal Ca-ATPase activity through induction of NO/cGMP pathway [2]. 14-DAG, in concentrations between 10-100 μM, reduced the extracellular acidification rate and the intracellular alkalinization in a dose-dependent manner. In addition, 14-DAG reduced PAF-induced calcium flux in the presence of extracellular calcium, and tyrosine phosphorylation of a 44 kDa protein corresponding to the MAPK(ERK1) [3].
In vivo	The protective effect of 14-DAG against ethanol-induced hepatic injury is based on its ability to reduce oxidative stress through cNOS dependent improvement of redox status. 14-DAG mediated activation of adenylate cyclase-cAMP signaling leading to the up-regulation of cNOS may provide a promising approach in the prevention of liver diseases during chronic alcoholism [4].
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 10 mg/mL (29.9 mM)
Keywords	Inhibitor \| proinflammatory \| mRNA \| inhibit \| LPS \| Interleukin Related \| neurite \| mediators \| Deoxyandrographolide \| outgrowth \| levels
Inhibitors Related	Inosine pranobex \| Amlexanox \| Glucosamine \| Dexamethasone acetate \| Thalidomide \| L-Arginine \| Apremilast \| Dexamethasone \| Lenalidomide \| Diallyl disulfide \| Fisetin \| Linalool
Related Compound Libraries	Anti-Tumor Natural Product Library \| Terpene Natural Product Library \| Bioactive Compound Library \| Traditional Chinese Medicine Monomer Library \| Rare Natural Product Library \| Selected Plant-Sourced Compound Library \| Anti-Inflammatory Traditional Chinese Medicine Compound Library \| Natural Product Library for HTS \| Anti-Aging Compound Library \| Bioactive Compounds Library Max

show more

Company Profile Introduction

You may like

Recommended supplier

MSDS|CAS|CAS DataBase|Pricacy|Terms|About Us|New Products| Contact us|Computer Version
Chemical Book