| Name | Dehydrocorydaline chloride |
| Description | Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid exhibiting anti-inflammatory and anti-cancer activities and can enhance the activation of p38 MAPK. |
| In vitro | Treatment of C2C12 myoblasts with 500 nM dehydrocorydrine increased the expression of muscle-specific proteins (including MyoD, myogenin, and myosin heavy chain), and enhanced p38 MAPK activation and the interaction between MyoD and E protein. Additionally, dehydrohydroxyproline restored defects in differentiation-induced p38 MAPK activation and differentiation of myoblasts caused by Cdo. Dehydrohydroxyproline significantly inhibited MCF-7 cell proliferation in a dose-dependent manner, reversible by the caspase-8 inhibitor Z-IETD-FMK. It also increased DNA fragmentation without affecting ΔΨm, elevated Bax protein levels, decreased Bcl-2 protein levels, and induced caspase-7 and -8 activation and PARP cleavage, without affecting caspase-9. These findings suggest that dehydrohydroxyproline inhibits MCF-7 cell proliferation by inducing apoptosis through Bax/Bcl-2 regulation, caspase activation, and PARP cleavage. |
| In vivo | Dehydrocobaltate (3.6, 6 or 10 mg/kg, intraperitoneal injection) showed a dose-dependent anti-nociceptive effect in the acetic acid-induced writhing test and significantly reduced formalin-induced mice Pain reaction. In the formalin test, dehydrocorydrine can reduce the expression of caspase 6 (CASP6), TNF-α, IL-1β and IL-6 proteins in the spinal cord. It was confirmed that dehydroyanhusine has an analgesic effect on mice. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 24 mg/mL (59.72 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (4.98 mM), Sonication is recommended.
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| Keywords | poly ADP ribose polymerase | PARP | Parasite | p38MAPK | p38 MAPK | Inhibitor | inhibit | Dehydrocorydaline chloride | Dehydrocorydaline Chloride | Dehydrocorydaline | caspase-8 | caspase-7 | Caspase | Bcl-2 Family | Bcl-2 | Bax | Autophagy | 13-Methylpalmatine Chloride | 13-Methylpalmatine |
| Inhibitors Related | Stavudine | Cysteamine hydrochloride | Kojic acid | Sodium 4-phenylbutyrate | Urethane | Hydroxychloroquine | Guanidine hydrochloride | Doxycycline | Paeonol | Naringin | Alginic acid | Gefitinib |
| Related Compound Libraries | Anti-Parasitic Compound Library | Bioactive Compound Library | Pain-Related Compound Library | Alkaloid Natural Product Library | Membrane Protein-targeted Compound Library | Kinase Inhibitor Library | Natural Product Library | Antiparasitic Natural Product Library | Anti-infective Natural Product Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library |
United States
