Name | DC-05 |
Description | DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively). |
In vitro | DC-05 is a non-nucleoside DNMT1 inhibitor with low micromolar IC50 values and significant selectivity toward other AdoMet-dependent protein methyltransferases.?DC-05 (1.25, 2.5, 5, and 10 μM) effectively inhibits the proliferation of HCT116 (human colon cancer) and Capan-1 (human pancreatic adenocarcinoma cells) after treatment for 24, 48, and 72 h. DC-05 displays poor potent activities against DNMT3A, DNMT3B, G9a, SUV39H1, MLL1, SET7/9, and PRMT1 (IC50: >200, >200, >150, >150, >150, >150, 37.1 μM) [1]. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 100 mg/mL (260.76 mM), Sonication is recommended.
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Keywords | Inhibitor | DC 05 | DC05 | DNMTs | DNA Methyltransferase | DNA MTases | DC-05 | inhibit |
Inhibitors Related | Levetiracetam | Tazemetostat | Piribedil | XY1 | 5-Azacytidine | GSK126 | EPZ015666 | Procainamide hydrochloride | Zebularine | γ-Oryzanol | MRTX-1719 | 5-Methyl-2'-deoxycytidine |
Related Compound Libraries | Reprogramming Compound Library | Histone Modification Compound Library | Methylation Compound Library | Bioactive Compound Library | Epigenetics Compound Library | Chromatin Modification Compound Library | Inhibitor Library | Stem Cell Differentiation Compound Library | NO PAINS Compound Library | Bioactive Compounds Library Max |