1. Product information
Names
| Name | 1-Amino-N-[3-(11,12-didehydrodibenzo[b,f]azocin-5(6H)-yl)-3-oxopropyl]-3,6,9,12-tetraoxapentadecan-15-amide |
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| Synonym | More Synonyms |
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DBCO-PEG(4)-NH2 Biological Activity
| Description | DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE (HY-15162) and antibody (e.g., DBCO-VCpAB−MMAE and DBCO-TRX−MMAE with EC50s of 280 nM and 22 nM in SKBR3 cells, respectively)[1]. |
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| Related Catalog | Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker |
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| Target | Cleavable |
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| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
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| References | [1]. Spangler B, et al. Toward a Ferrous Iron-Cleavable Linker for Antibody-Drug Conjugates. Mol Pharm. 2018 May 7;15(5):2054-2059. . |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 784.1±60.0 °C at 760 mmHg |
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| Molecular Formula | C29H37N3O6 |
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| Molecular Weight | 523.621 |
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| Flash Point | 428.0±32.9 °C |
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| Exact Mass | 523.268250 |
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| LogP | 1.56 |
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| Vapour Pressure | 0.0±2.7 mmHg at 25°C |
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| Index of Refraction | 1.595 |
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Synonyms
| 3,6,9,12-Tetraoxapentadecan-15-amide, 1-amino-N-[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]- |
| 1-Amino-N-[3-(11,12-didehydrodibenzo[b,f]azocin-5(6H)-yl)-3-oxopropyl]-3,6,9,12-tetraoxapentadecan-15-amide |
2. Packaging
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping
4. Contact information
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