Dasatinib

Product Name: Dasatinib
Synonyms: SPRYCEL;BMS354825;DASATINIB (BMS 354825);CS-1968;N-(2-chloro-6-Methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-Methyl-4-pyriMidinyl]aMino]-1,3-thiazole-5-carboxaMide;sprycel Dasatinib;BMS-354825; SPRYCEL;25MG/100MG/1G;NCGC00181129;Dasatinib (Dasatinib Monohydrate) Tablet
CAS: 302962-49-8
MF: C22H28ClN7O3S
MW: 488.01
EINECS: 801-607-0

Melting point: 275-286°C
Boiling point: 329.1±15.0 °C
Density: 1.408±0.06 g/cm3
Storage temp.: -20°C Freezer
Appearance: White Powder

Description:

Dasatinib is available in 20-, 50-, and 70-mg tablets fororal administration in the treatment of CML and ALL thatare Ph1 positive. Although dasatinib is more potent thanimatinib, bioavailability is much lower with values rangingbetween 14% to 34%. The agent is extensively metabolizedwith as many as 29 metabolites seen as result of oxidationby primarily CYP3A4 and phase II conjugation.The agent may act as an inhibitor of CYP3A4 andCYP2C8. Metabolism does give an active metabolite, but this accounts for only 5% of the total and is not believed tobe important for the overall activity of the agent. Dasatinibis 95% protein bound with a terminal half-life of 3 to5 hours. The majority of the drug and metabolites are eliminatedin the feces. The most common side effects are skinrash, nausea, diarrhea, and fatigue. Serious side effects includemyelosuppression appearing as neutropenia andthrombocytopenia, bleeding of the brain and GI tract, andfluid retention.

Uses:

Suitable for treatment of chronic myeloid leukemia which is resistant or intolerant to the treating programs including imatinib mesylate.

1. Quality
Our products meet MSDS safe standard and we have ISO and other certificate so yan can get high quality products from our company.
2. Price
We are the company which is the joint of trade and industry so we cao provide the competitive price and high quality product.
3.Packing
Generally, the package is 25 kg.
But,we can do according to the customers' request.
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      Our company provides chemical raw materials, chemical products, pharmaceutical intermediates, veterinary intermediates, dye intermediates, pigments, cosmetic raw materials, chemical reagents and PVC particles to meet your various needs.
      With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements.
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      Our plant has strict quality control in each manufacturing process. Guaranteed.Meanwhile all the materials are tested before each shipment in our laboratory to double confirm the quality.
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      Our company is committed to the production and development of titanium dioxide, we always offer the most competitive pricing to customers to help lower their cost in application.
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      90% of orders are shipped within 7-10 days after receipt of the prepayment or Western union
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