Dabigatran ethyl ester hydrochloride NEW

$47.00 5mg

$89.00 10mg

$163.00 25mg

Min. Order
Purity98.7%
Cas No211914-50-0
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

5YR

United States

Since2011-01-07

Address36 Washington Street, Wellesley Hills

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Chemical Properties

Product Name	Dabigatran ethyl ester hydrochloride
CAS No	211914-50-0
EC-No
Min. Order
Purity	98.7%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	Dabigatran ethyl ester hydrochloride
Description	Dabigatran ethyl ester hydrochloride is an effective inhibitor of ribosyl dihydronicotinic acid amide dehydrogenase (NQO2) with an IC50 value of 0.8 μM and is a thrombin inhibitor.
In vitro	Dabigatran (ethyl ester hydrochloride) has a Ki of 0.9 μM for NQO2 and an IC50 of 0.8 μM. The ethyl group (ethyl ester hydrochloride) of dabigatran significantly extends the interaction surface, especially with hydrophobic amino acids (such as Ile 128 and Met 154). Dabigatran ethyl ester has a higher affinity for thrombin and NQO2 than dabigatran [1]. Dabigatran is a highly selective, reversible and effective thrombin inhibitor, which can be taken orally as a prodrug dabigatran etexilate .
In vivo	Dabigatran (Ki = 4.5 nM) can selectively bind to human thrombin and reversibly achieve a strong and lasting anticoagulant effect.
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 50 mg/mL (93.28 mM) H2O : 5 mg/mL (9.33 mM), Sonication is recommended.
Keywords	Dabigatran ethyl ester \| inhibit \| Inhibitor \| Dabigatran ethyl ester hydrochloride \| Dabigatran ethyl ester Hydrochloride \| Thrombin
Inhibitors Related	Dabigatran Etexilate Mesylate \| (S)-(+)-Ibuprofen \| Edoxaban \| AEBSF hydrochloride \| Heparin sodium salt \| Thrombin (MW 37kDa) \| Menadione \| Ozagrel \| Avatrombopag \| Argatroban \| Eltrombopag Olamine \| p-Hydroxycinnamic acid
Related Compound Libraries	Bioactive Compound Library \| Protease Inhibitor Library \| Inhibitor Library \| Orally Active Compound Library \| Bioactive Compounds Library Max

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Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.