| Name | D609 |
| Description | D609 (Tricyclodecan-9-yl-Xanthogenate) has a wide range of biological activities including antioxidant, antiapoptotic, anticholinergic, antitumor, anti-inflammatory, antiviral, antiproliferative, and neuroprotective activities.D609 acts by inducing competitive inhibition of PC-specific phospholipase C (PC-PLC) and sphingomyelin synthase (SMS). D609 acts by causing competitive inhibition of PC-specific phospholipase C (PC-PLC) and sphingomyelin synthase (SMS). |
| In vitro | D609 (100 μM; 2 hours) significantly inhibits the proliferation of various cell lines[2].At concentrations of 50, 100, and 200 μM (2 hours), D609 activates caspase-3 at 200 μM, while at 50 and 100 μM, no detectable cleavage is observed[2].D609 (100 μM; 2 hours) markedly inhibits BrdU incorporation in BV-2 microglial cells, leading to G1 phase cell accumulation and a decrease in the number of cells in the S phase[2].D609 (100 μM; 2 hours, followed by 2 or 22 hours of cultivation without D609) increases ceramide levels, upregulates p21 expression, and results in decreased phosphorylation of Rb[4]. |
| In vivo | D609 (2.5 and 10 mg/kg/day; intraperitoneal injection; continuous for 6 weeks) inhibits the progression of pre-existing atherosclerotic lesions in apoE-/- mice and transforms the lesion composition into a more stable phenotype[3].Pre-treatment with D609 (50 mg/kg; intraperitoneal injection; single dose) 30 minutes before intratracheal administration of LPS (3 mg/kg) prevents lipopolysaccharide-induced pulmonary arterial hypertension in adult male Wistar rats[2]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 1 mg/mL (3.75 mM), Sonication is recommended.
DMSO : 80 mg/mL (300.23 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2.5 mg/mL (9.38 mM), Sonication is recommended.
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| Keywords | PC-PLC | D-609 | D609 | D 609 | Apoptosis | Antioxidant |
| Inhibitors Related | Neomycin sulfate | Stavudine | Aceglutamide | Tamoxifen | Urea | Cysteamine hydrochloride | Gum arabic | Metronidazole | Citric Acid Triammonium | Dimethyl phthalate | Alginic acid | Dextran sulfate sodium salt (MW 5000) |
| Related Compound Libraries | Apoptosis Compound Library | Bioactive Compound Library | Antioxidant Compound Library | Anti-Viral Compound Library | Neuroprotective Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Infection Compound Library | Anti-Cancer Active Compound Library |
United States
