| Name | (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) acetate |
| Description | (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) acetate is a highly potent antagonist of parathyroid hormone (PTH) The Ki value is 69 nM in bovine renal cortical membrane. |
| In vitro | In opossum kidney (OK) cells, (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) acetate (0.05-10 μM) inhibits PTHrP or PTH-stimulated cAMP formation in causes a concentration-dependent manner. (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) acetate (0.1-10 μM) attenuates the inhibition of NapiT promoted by 1 nM of either PTHrP or PTH[1]. |
| In vivo | In hypercalcemic athymic nude mice bearing a human squamous cell carcinoma of the lung, administration of (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) acetate (1 mg/mL once, 0.1 mg/mL for 6 h; i.v.) has no significant effect on serum calcium levels[2]. |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 50 mg/mL, Sonication is recommended.
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| Keywords | Thyroidhormonereceptor(THR) | Thyroidhormonereceptor | Thyroid hormone receptor(THR) | Thyroid hormone receptor | THR | (D-Trp-12,Tyr34)-pTH (7-34) amide (bovine) acetate | (DTrp12,Tyr34)pTH (734) amide (bovine) acetate | (D-Trp12,Tyr34)-pTH amide Acetate | (D-Trp12,Tyr34)-pTH | (D Trp12,Tyr34) pTH (7 34) amide (bovine) acetate |
| Inhibitors Related | Propylthiouracil | Azetirelin | Liothyronine | L-Thyroxine | L-Thyroxine sodium | Resmetirom | 2,2-BIS(2-HYDROXY-5-BIPHENYLYL)PROPANE | DS08210767 | Carbimazole | 2-Thiouracil | PCO371 | Tiratricol |
| Related Compound Libraries | Peptide Compound Library |