Name | (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) acetate |
Description | (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) acetate is a highly potent antagonist of parathyroid hormone (PTH) The Ki value is 69 nM in bovine renal cortical membrane. |
In vitro | In opossum kidney (OK) cells, (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) acetate (0.05-10 μM) inhibits PTHrP or PTH-stimulated cAMP formation in causes a concentration-dependent manner. (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) acetate (0.1-10 μM) attenuates the inhibition of NapiT promoted by 1 nM of either PTHrP or PTH[1]. |
In vivo | In hypercalcemic athymic nude mice bearing a human squamous cell carcinoma of the lung, administration of (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) acetate (1 mg/mL once, 0.1 mg/mL for 6 h; i.v.) has no significant effect on serum calcium levels[2]. |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 50 mg/ml
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Keywords | (D Trp12,Tyr34) pTH (7 34) amide (bovine) acetate | (D-Trp12,Tyr34)-pTH | (D-Trp-12,Tyr34)-pTH (7-34) amide (bovine) acetate | (DTrp12,Tyr34)pTH (734) amide (bovine) acetate | (D-Trp12,Tyr34)-pTH amide Acetate |
Inhibitors Related | Propylthiouracil | Liothyronine | L-Thyroxine | L-Thyroxine sodium | 2,2-BIS(2-HYDROXY-5-BIPHENYLYL)PROPANE | Resmetirom | Carbimazole | Liothyronine sodium | 2-Thiouracil | Tiratricol |
Related Compound Libraries | Peptide Compound Library |